Cargando…

Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study

BACKGROUND AND OBJECTIVES: Overweight and obesity are among the important challenges in health issues and survival of elderly people. The current study aimed to evaluate the survival rate of elderly patients with diabetes, and its influencing factors, on the basis of body mass index (BMI). METHODS A...

Descripción completa

Detalles Bibliográficos
Autores principales: Bijani, Ali, Cumming, Robert G., Hosseini, Seyed-Reza, Yazdanpour, Masoumeh, Rahimi, Mahdis, Sahebian, Abbas, Ghadimi, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154521/
https://www.ncbi.nlm.nih.gov/pubmed/30288385
http://dx.doi.org/10.1007/s40200-018-0337-7
_version_ 1783357703717912576
author Bijani, Ali
Cumming, Robert G.
Hosseini, Seyed-Reza
Yazdanpour, Masoumeh
Rahimi, Mahdis
Sahebian, Abbas
Ghadimi, Reza
author_facet Bijani, Ali
Cumming, Robert G.
Hosseini, Seyed-Reza
Yazdanpour, Masoumeh
Rahimi, Mahdis
Sahebian, Abbas
Ghadimi, Reza
author_sort Bijani, Ali
collection PubMed
description BACKGROUND AND OBJECTIVES: Overweight and obesity are among the important challenges in health issues and survival of elderly people. The current study aimed to evaluate the survival rate of elderly patients with diabetes, and its influencing factors, on the basis of body mass index (BMI). METHODS AND MATERIALS: The design of the current study was based on the Amirkola Health and Aging Project (AHAP) cohort. The 5–year survival rate of elderly people with diabetes and the factors that influence the mortality rate by Cox regression model were analyzed. RESULTS: Out of 1616 elderly people who were evaluated in the current study, 501 (31%) had diabetes. The results showed that diabetes significantly increased the mortality rate (adjusted hazard ratio [HR] = 2.10; 95% confidence interval [CI]: 1.57–2.81; P < 0.001). Furthermore, overweight (HR = 0.41; 95%CI: 0.24–0.75; P = 0.002), obesity (HR = 0.30; 95% CI: 0.41–0.63; P = 0.002), history of diabetes (HR = 0.56; 95%CI: 0.34–0.93; P = 0.024), moderate and high physical activity level (HR = 0.36; 95%CI: 0.13–0.99; P = 0.049) decreased the risk of mortality and central obesity (HR = 1.76; 95% CI: 1.01–3.11; P = 0.049), fasting blood sugar ≥200 (HR = 2.46; 95% CI: 1.46–4.15; P < 0.001), brain stroke, and neurological diseases (HR = 3.12; 95% CI: 1.78–5.49; P < 0.001) increased the risk of mortality. CONCLUSION: Although overweight and obesity significantly improved the risk of mortality in elderly patients with diabetes, central obesity is still considered as an important risk factor.
format Online
Article
Text
id pubmed-6154521
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-61545212019-04-11 Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study Bijani, Ali Cumming, Robert G. Hosseini, Seyed-Reza Yazdanpour, Masoumeh Rahimi, Mahdis Sahebian, Abbas Ghadimi, Reza J Diabetes Metab Disord Research Article BACKGROUND AND OBJECTIVES: Overweight and obesity are among the important challenges in health issues and survival of elderly people. The current study aimed to evaluate the survival rate of elderly patients with diabetes, and its influencing factors, on the basis of body mass index (BMI). METHODS AND MATERIALS: The design of the current study was based on the Amirkola Health and Aging Project (AHAP) cohort. The 5–year survival rate of elderly people with diabetes and the factors that influence the mortality rate by Cox regression model were analyzed. RESULTS: Out of 1616 elderly people who were evaluated in the current study, 501 (31%) had diabetes. The results showed that diabetes significantly increased the mortality rate (adjusted hazard ratio [HR] = 2.10; 95% confidence interval [CI]: 1.57–2.81; P < 0.001). Furthermore, overweight (HR = 0.41; 95%CI: 0.24–0.75; P = 0.002), obesity (HR = 0.30; 95% CI: 0.41–0.63; P = 0.002), history of diabetes (HR = 0.56; 95%CI: 0.34–0.93; P = 0.024), moderate and high physical activity level (HR = 0.36; 95%CI: 0.13–0.99; P = 0.049) decreased the risk of mortality and central obesity (HR = 1.76; 95% CI: 1.01–3.11; P = 0.049), fasting blood sugar ≥200 (HR = 2.46; 95% CI: 1.46–4.15; P < 0.001), brain stroke, and neurological diseases (HR = 3.12; 95% CI: 1.78–5.49; P < 0.001) increased the risk of mortality. CONCLUSION: Although overweight and obesity significantly improved the risk of mortality in elderly patients with diabetes, central obesity is still considered as an important risk factor. Springer International Publishing 2018-04-11 /pmc/articles/PMC6154521/ /pubmed/30288385 http://dx.doi.org/10.1007/s40200-018-0337-7 Text en © Springer International Publishing AG 2018
spellingShingle Research Article
Bijani, Ali
Cumming, Robert G.
Hosseini, Seyed-Reza
Yazdanpour, Masoumeh
Rahimi, Mahdis
Sahebian, Abbas
Ghadimi, Reza
Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study
title Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study
title_full Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study
title_fullStr Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study
title_full_unstemmed Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study
title_short Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study
title_sort obesity paradox on the survival of elderly patients with diabetes: an ahap-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154521/
https://www.ncbi.nlm.nih.gov/pubmed/30288385
http://dx.doi.org/10.1007/s40200-018-0337-7
work_keys_str_mv AT bijaniali obesityparadoxonthesurvivalofelderlypatientswithdiabetesanahapbasedstudy
AT cummingrobertg obesityparadoxonthesurvivalofelderlypatientswithdiabetesanahapbasedstudy
AT hosseiniseyedreza obesityparadoxonthesurvivalofelderlypatientswithdiabetesanahapbasedstudy
AT yazdanpourmasoumeh obesityparadoxonthesurvivalofelderlypatientswithdiabetesanahapbasedstudy
AT rahimimahdis obesityparadoxonthesurvivalofelderlypatientswithdiabetesanahapbasedstudy
AT sahebianabbas obesityparadoxonthesurvivalofelderlypatientswithdiabetesanahapbasedstudy
AT ghadimireza obesityparadoxonthesurvivalofelderlypatientswithdiabetesanahapbasedstudy