Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK

The involvement of protein kinase CK1δ in the pathogenesis of severe disorders such as Alzheimer’s disease, amyotrophic lateral sclerosis, familial advanced sleep phase syndrome, and cancer has dramatically increased interest in the development of effective small molecule inhibitors for both therape...

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Detalles Bibliográficos
Autores principales: Halekotte, Jakob, Witt, Lydia, Ianes, Chiara, Krüger, Marc, Bührmann, Mike, Rauh, Daniel, Pichlo, Christian, Brunstein, Elena, Luxenburger, Andreas, Baumann, Ulrich, Knippschild, Uwe, Bischof, Joachim, Peifer, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154583/
https://www.ncbi.nlm.nih.gov/pubmed/28338621
http://dx.doi.org/10.3390/molecules22040522

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