Cs(2)CO(3)-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers

It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom-economic process for this anionic trifluoromethylati...

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Detalles Bibliográficos
Autores principales: Dong, Cheng, Bai, Xing-Feng, Lv, Ji-Yuan, Cui, Yu-Ming, Cao, Jian, Zheng, Zhan-Jiang, Xu, Li-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154635/
https://www.ncbi.nlm.nih.gov/pubmed/28524100
http://dx.doi.org/10.3390/molecules22050769
Descripción
Sumario:It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom-economic process for this anionic trifluoromethylation of non-enolisable aldehydes and ketones.

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