Cs(2)CO(3)-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers

It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom-economic process for this anionic trifluoromethylati...

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Autores principales: Dong, Cheng, Bai, Xing-Feng, Lv, Ji-Yuan, Cui, Yu-Ming, Cao, Jian, Zheng, Zhan-Jiang, Xu, Li-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154635/
https://www.ncbi.nlm.nih.gov/pubmed/28524100
http://dx.doi.org/10.3390/molecules22050769
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author Dong, Cheng
Bai, Xing-Feng
Lv, Ji-Yuan
Cui, Yu-Ming
Cao, Jian
Zheng, Zhan-Jiang
Xu, Li-Wen
author_facet Dong, Cheng
Bai, Xing-Feng
Lv, Ji-Yuan
Cui, Yu-Ming
Cao, Jian
Zheng, Zhan-Jiang
Xu, Li-Wen
author_sort Dong, Cheng
collection PubMed
description It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom-economic process for this anionic trifluoromethylation of non-enolisable aldehydes and ketones.
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spelling pubmed-61546352018-11-13 Cs(2)CO(3)-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers Dong, Cheng Bai, Xing-Feng Lv, Ji-Yuan Cui, Yu-Ming Cao, Jian Zheng, Zhan-Jiang Xu, Li-Wen Molecules Article It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom-economic process for this anionic trifluoromethylation of non-enolisable aldehydes and ketones. MDPI 2017-05-18 /pmc/articles/PMC6154635/ /pubmed/28524100 http://dx.doi.org/10.3390/molecules22050769 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dong, Cheng
Bai, Xing-Feng
Lv, Ji-Yuan
Cui, Yu-Ming
Cao, Jian
Zheng, Zhan-Jiang
Xu, Li-Wen
Cs(2)CO(3)-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers
title Cs(2)CO(3)-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers
title_full Cs(2)CO(3)-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers
title_fullStr Cs(2)CO(3)-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers
title_full_unstemmed Cs(2)CO(3)-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers
title_short Cs(2)CO(3)-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers
title_sort cs(2)co(3)-initiated trifluoro-methylation of chalcones and ketones for practical synthesis of trifluoromethylated tertiary silyl ethers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154635/
https://www.ncbi.nlm.nih.gov/pubmed/28524100
http://dx.doi.org/10.3390/molecules22050769
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