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Metajapogenins A–C, Pregnane Steroids from Shells of Metaplexis japonica
Phytochemical investigation of the shells of Metaplexis japonica (Thunb.) Makino, belonging to the family of Apocynaceae, afforded three new pregnane steroids, metajapogenins A–C, along with three known compounds. The structures of the new compounds were elucidated as 12β,14β,17β-trihydroxypregna-3,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154641/ https://www.ncbi.nlm.nih.gov/pubmed/28420184 http://dx.doi.org/10.3390/molecules22040646 |
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author | Yao, Hui-Li Liu, Yang Liu, Xiao-Hong Gao, Hua Liu, Kun Shao, Yan-Lin Fang, Xin-Yu Wang, Wei |
author_facet | Yao, Hui-Li Liu, Yang Liu, Xiao-Hong Gao, Hua Liu, Kun Shao, Yan-Lin Fang, Xin-Yu Wang, Wei |
author_sort | Yao, Hui-Li |
collection | PubMed |
description | Phytochemical investigation of the shells of Metaplexis japonica (Thunb.) Makino, belonging to the family of Apocynaceae, afforded three new pregnane steroids, metajapogenins A–C, along with three known compounds. The structures of the new compounds were elucidated as 12β,14β,17β-trihydroxypregna-3,5-dien-7,20-dione, 12β,14β,17β,20β-tetrahydroxypregna-3,5-dien-7-one; 3β,12β,14β,17β-tetrahydroxypregn-5-ene-7,20-dione on the basis of extensive spectroscopic evidence derived from 1D; 2D-NMR experiments and mass spectrometry. The known compounds included pergularin; 12-O-acetylpergularin; and pergularin-3-O-β-d-oleandropyranose; which were identified for the first time in the shells of M. japonica. |
format | Online Article Text |
id | pubmed-6154641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61546412018-11-13 Metajapogenins A–C, Pregnane Steroids from Shells of Metaplexis japonica Yao, Hui-Li Liu, Yang Liu, Xiao-Hong Gao, Hua Liu, Kun Shao, Yan-Lin Fang, Xin-Yu Wang, Wei Molecules Article Phytochemical investigation of the shells of Metaplexis japonica (Thunb.) Makino, belonging to the family of Apocynaceae, afforded three new pregnane steroids, metajapogenins A–C, along with three known compounds. The structures of the new compounds were elucidated as 12β,14β,17β-trihydroxypregna-3,5-dien-7,20-dione, 12β,14β,17β,20β-tetrahydroxypregna-3,5-dien-7-one; 3β,12β,14β,17β-tetrahydroxypregn-5-ene-7,20-dione on the basis of extensive spectroscopic evidence derived from 1D; 2D-NMR experiments and mass spectrometry. The known compounds included pergularin; 12-O-acetylpergularin; and pergularin-3-O-β-d-oleandropyranose; which were identified for the first time in the shells of M. japonica. MDPI 2017-04-17 /pmc/articles/PMC6154641/ /pubmed/28420184 http://dx.doi.org/10.3390/molecules22040646 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yao, Hui-Li Liu, Yang Liu, Xiao-Hong Gao, Hua Liu, Kun Shao, Yan-Lin Fang, Xin-Yu Wang, Wei Metajapogenins A–C, Pregnane Steroids from Shells of Metaplexis japonica |
title | Metajapogenins A–C, Pregnane Steroids from Shells of Metaplexis japonica |
title_full | Metajapogenins A–C, Pregnane Steroids from Shells of Metaplexis japonica |
title_fullStr | Metajapogenins A–C, Pregnane Steroids from Shells of Metaplexis japonica |
title_full_unstemmed | Metajapogenins A–C, Pregnane Steroids from Shells of Metaplexis japonica |
title_short | Metajapogenins A–C, Pregnane Steroids from Shells of Metaplexis japonica |
title_sort | metajapogenins a–c, pregnane steroids from shells of metaplexis japonica |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154641/ https://www.ncbi.nlm.nih.gov/pubmed/28420184 http://dx.doi.org/10.3390/molecules22040646 |
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