Cargando…
Possible Involvement of Hydrosulfide in B(12)-Dependent Methyl Group Transfer
Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B(12)-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154648/ https://www.ncbi.nlm.nih.gov/pubmed/28379205 http://dx.doi.org/10.3390/molecules22040582 |
_version_ | 1783357732734107648 |
---|---|
author | Toohey, John I. |
author_facet | Toohey, John I. |
author_sort | Toohey, John I. |
collection | PubMed |
description | Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B(12)-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H(2)S), hydrosulfide derivatives of cobalamins, autoxidation of hydrosulfide radical, radical S-adenosylmethionine methyl transfer (RSMT), and methionine synthase (MS). Then, new reaction mechanisms for B(12)-dependent methyl group transfer are proposed; the mechanisms are facile and overcome difficulties that existed in previously-accepted mechanisms. Finally, the theory is applied to the effect of S°/H(2)S in nerve tissue involving the “hypomethylation theory” that was proposed 50 years ago to explain the neuropathology resulting from deficiency of vitamin B(12) or folic acid. The conclusions are consistent with emerging evidence that sulfane sulfur/hydrogen sulfide may be beneficial in treating Alzheimer’s disease. |
format | Online Article Text |
id | pubmed-6154648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61546482018-11-13 Possible Involvement of Hydrosulfide in B(12)-Dependent Methyl Group Transfer Toohey, John I. Molecules Hypothesis Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B(12)-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H(2)S), hydrosulfide derivatives of cobalamins, autoxidation of hydrosulfide radical, radical S-adenosylmethionine methyl transfer (RSMT), and methionine synthase (MS). Then, new reaction mechanisms for B(12)-dependent methyl group transfer are proposed; the mechanisms are facile and overcome difficulties that existed in previously-accepted mechanisms. Finally, the theory is applied to the effect of S°/H(2)S in nerve tissue involving the “hypomethylation theory” that was proposed 50 years ago to explain the neuropathology resulting from deficiency of vitamin B(12) or folic acid. The conclusions are consistent with emerging evidence that sulfane sulfur/hydrogen sulfide may be beneficial in treating Alzheimer’s disease. MDPI 2017-04-05 /pmc/articles/PMC6154648/ /pubmed/28379205 http://dx.doi.org/10.3390/molecules22040582 Text en © 2017 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Hypothesis Toohey, John I. Possible Involvement of Hydrosulfide in B(12)-Dependent Methyl Group Transfer |
title | Possible Involvement of Hydrosulfide in B(12)-Dependent Methyl Group Transfer |
title_full | Possible Involvement of Hydrosulfide in B(12)-Dependent Methyl Group Transfer |
title_fullStr | Possible Involvement of Hydrosulfide in B(12)-Dependent Methyl Group Transfer |
title_full_unstemmed | Possible Involvement of Hydrosulfide in B(12)-Dependent Methyl Group Transfer |
title_short | Possible Involvement of Hydrosulfide in B(12)-Dependent Methyl Group Transfer |
title_sort | possible involvement of hydrosulfide in b(12)-dependent methyl group transfer |
topic | Hypothesis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154648/ https://www.ncbi.nlm.nih.gov/pubmed/28379205 http://dx.doi.org/10.3390/molecules22040582 |
work_keys_str_mv | AT tooheyjohni possibleinvolvementofhydrosulfideinb12dependentmethylgrouptransfer |