New Glycosides from the Fruits of Nicandra physaloides

Three new glycosides (1–3) and 15 known ones (4–18) were isolated and identified from the fruits of Nicandra physaloides. The structures of these compounds were established by 1D and 2D NMR spectra and HR-ESI-MS. The compounds (4–18) were the first time isolated from the Nicandra genus and they (exc...

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Detalles Bibliográficos
Autores principales: Liu, Yan, Jiang, Hai-Bing, Xu, Zhen-Peng, Cheng, Yan-Gang, Lv, Shao-Wa, Yang, Bing-You, Guo, Hong-Wei, Kuang, Hai-Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154662/
https://www.ncbi.nlm.nih.gov/pubmed/28513563
http://dx.doi.org/10.3390/molecules22050828
Descripción
Sumario:Three new glycosides (1–3) and 15 known ones (4–18) were isolated and identified from the fruits of Nicandra physaloides. The structures of these compounds were established by 1D and 2D NMR spectra and HR-ESI-MS. The compounds (4–18) were the first time isolated from the Nicandra genus and they (except 8, 10, 14) exhibited inhibitions on the NO release of LPS-induced RAW 264.7 cells with IC(50) values from 26.9 to 47.5 μM.

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