Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl.

Three new abietane-type diterpenoids, named callicapoic acid M3 (1), callicapoic acid M4 (2) and callicapoic acid M5 (3), were isolated from the Callicarpa macrophylla Vahl. Their structures were established by spectroscopic techniques (IR, UV, MS, 1D and 2D NMR). All the isolated three compounds we...

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Autores principales: Wang, Zhen-Hui, Niu, Chao, Zhou, De-Jun, Kong, Ji-Chuan, Zhang, Wen-Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154670/
https://www.ncbi.nlm.nih.gov/pubmed/28534843
http://dx.doi.org/10.3390/molecules22050842
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author Wang, Zhen-Hui
Niu, Chao
Zhou, De-Jun
Kong, Ji-Chuan
Zhang, Wen-Kui
author_facet Wang, Zhen-Hui
Niu, Chao
Zhou, De-Jun
Kong, Ji-Chuan
Zhang, Wen-Kui
author_sort Wang, Zhen-Hui
collection PubMed
description Three new abietane-type diterpenoids, named callicapoic acid M3 (1), callicapoic acid M4 (2) and callicapoic acid M5 (3), were isolated from the Callicarpa macrophylla Vahl. Their structures were established by spectroscopic techniques (IR, UV, MS, 1D and 2D NMR). All the isolated three compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds 1, 2 and 3 showed potent inhibitory activity, with inhibition rates of 34.47–40.13%.
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spelling pubmed-61546702018-11-13 Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl. Wang, Zhen-Hui Niu, Chao Zhou, De-Jun Kong, Ji-Chuan Zhang, Wen-Kui Molecules Article Three new abietane-type diterpenoids, named callicapoic acid M3 (1), callicapoic acid M4 (2) and callicapoic acid M5 (3), were isolated from the Callicarpa macrophylla Vahl. Their structures were established by spectroscopic techniques (IR, UV, MS, 1D and 2D NMR). All the isolated three compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds 1, 2 and 3 showed potent inhibitory activity, with inhibition rates of 34.47–40.13%. MDPI 2017-05-19 /pmc/articles/PMC6154670/ /pubmed/28534843 http://dx.doi.org/10.3390/molecules22050842 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Zhen-Hui
Niu, Chao
Zhou, De-Jun
Kong, Ji-Chuan
Zhang, Wen-Kui
Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl.
title Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl.
title_full Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl.
title_fullStr Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl.
title_full_unstemmed Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl.
title_short Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl.
title_sort three new abietane-type diterpenoids from callicarpa macrophylla vahl.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154670/
https://www.ncbi.nlm.nih.gov/pubmed/28534843
http://dx.doi.org/10.3390/molecules22050842
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