Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation

An efficient, convenient, and eco-friendly biocatalytic approach was developed for the synthesis of quinoline derivatives via the α-chymotrypsin-catalyzed Friedländer reaction. Interestingly, α-chymotrypsin exhibited higher catalytic activity in an ionic liquid (IL) aqueous solution as compared to t...

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Autores principales: Le, Zhang-Gao, Liang, Meng, Chen, Zhong-Sheng, Zhang, Sui-Hong, Xie, Zong-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154722/
https://www.ncbi.nlm.nih.gov/pubmed/28481323
http://dx.doi.org/10.3390/molecules22050762
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author Le, Zhang-Gao
Liang, Meng
Chen, Zhong-Sheng
Zhang, Sui-Hong
Xie, Zong-Bo
author_facet Le, Zhang-Gao
Liang, Meng
Chen, Zhong-Sheng
Zhang, Sui-Hong
Xie, Zong-Bo
author_sort Le, Zhang-Gao
collection PubMed
description An efficient, convenient, and eco-friendly biocatalytic approach was developed for the synthesis of quinoline derivatives via the α-chymotrypsin-catalyzed Friedländer reaction. Interestingly, α-chymotrypsin exhibited higher catalytic activity in an ionic liquid (IL) aqueous solution as compared to that observed in our previous relevant study, which was conducted using an organic solvent, and a series of substrates gave similar excellent yields at lower reaction temperature and under reduced enzyme-loading conditions.
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spelling pubmed-61547222018-11-13 Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation Le, Zhang-Gao Liang, Meng Chen, Zhong-Sheng Zhang, Sui-Hong Xie, Zong-Bo Molecules Article An efficient, convenient, and eco-friendly biocatalytic approach was developed for the synthesis of quinoline derivatives via the α-chymotrypsin-catalyzed Friedländer reaction. Interestingly, α-chymotrypsin exhibited higher catalytic activity in an ionic liquid (IL) aqueous solution as compared to that observed in our previous relevant study, which was conducted using an organic solvent, and a series of substrates gave similar excellent yields at lower reaction temperature and under reduced enzyme-loading conditions. MDPI 2017-05-08 /pmc/articles/PMC6154722/ /pubmed/28481323 http://dx.doi.org/10.3390/molecules22050762 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Le, Zhang-Gao
Liang, Meng
Chen, Zhong-Sheng
Zhang, Sui-Hong
Xie, Zong-Bo
Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation
title Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation
title_full Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation
title_fullStr Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation
title_full_unstemmed Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation
title_short Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation
title_sort ionic liquid as an efficient medium for the synthesis of quinoline derivatives via α-chymotrypsin-catalyzed friedländer condensation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154722/
https://www.ncbi.nlm.nih.gov/pubmed/28481323
http://dx.doi.org/10.3390/molecules22050762
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AT liangmeng ionicliquidasanefficientmediumforthesynthesisofquinolinederivativesviaachymotrypsincatalyzedfriedlandercondensation
AT chenzhongsheng ionicliquidasanefficientmediumforthesynthesisofquinolinederivativesviaachymotrypsincatalyzedfriedlandercondensation
AT zhangsuihong ionicliquidasanefficientmediumforthesynthesisofquinolinederivativesviaachymotrypsincatalyzedfriedlandercondensation
AT xiezongbo ionicliquidasanefficientmediumforthesynthesisofquinolinederivativesviaachymotrypsincatalyzedfriedlandercondensation

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