Genetically enhancing the expression of chemokine domain of CX(3)CL1 fails to prevent tau pathology in mouse models of tauopathy

BACKGROUND: Fractalkine (CX(3)CL1) and its receptor (CX(3)CR1) play an important role in regulating microglial function. We have previously shown that Cx(3)cr1 deficiency exacerbated tau pathology and led to cognitive impairment. However, it is still unclear if the chemokine domain of the ligand CX(...

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Detalles Bibliográficos
Autores principales: Bemiller, Shane M., Maphis, Nicole M., Formica, Shane V., Wilson, Gina N., Miller, Crystal M., Xu, Guixiang, Kokiko-Cochran, Olga N., Kim, Ki-Wook, Jung, Steffen, Cannon, Judy L., Crish, Samuel D., Cardona, Astrid E., Lamb, Bruce T., Bhaskar, Kiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154806/
https://www.ncbi.nlm.nih.gov/pubmed/30253780
http://dx.doi.org/10.1186/s12974-018-1310-6

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