Dynamic ERK signaling regulation in intestinal tumorigenesis

Extracellular signal-regulated kinase (ERK) plays a critical role in tissue homeostasis and tumorigenesis. By utilizing live imaging approaches, we recently uncovered ERK activity dynamics in the intestinal epithelium. Notably, we showed that ERK activity dynamics are defined by composite regulation...

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Detalles Bibliográficos
Autores principales: Muta, Yu, Matsuda, Michiyuki, Imajo, Masamichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154845/
https://www.ncbi.nlm.nih.gov/pubmed/30263947
http://dx.doi.org/10.1080/23723556.2018.1506684
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author Muta, Yu
Matsuda, Michiyuki
Imajo, Masamichi
author_facet Muta, Yu
Matsuda, Michiyuki
Imajo, Masamichi
author_sort Muta, Yu
collection PubMed
description Extracellular signal-regulated kinase (ERK) plays a critical role in tissue homeostasis and tumorigenesis. By utilizing live imaging approaches, we recently uncovered ERK activity dynamics in the intestinal epithelium. Notably, we showed that ERK activity dynamics are defined by composite regulation from two distinct upstream receptors, and alteration of their functional balance underlies tumor cell-specific traits. Here, we discuss these findings.
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spelling pubmed-61548452019-09-11 Dynamic ERK signaling regulation in intestinal tumorigenesis Muta, Yu Matsuda, Michiyuki Imajo, Masamichi Mol Cell Oncol Author’s Views Extracellular signal-regulated kinase (ERK) plays a critical role in tissue homeostasis and tumorigenesis. By utilizing live imaging approaches, we recently uncovered ERK activity dynamics in the intestinal epithelium. Notably, we showed that ERK activity dynamics are defined by composite regulation from two distinct upstream receptors, and alteration of their functional balance underlies tumor cell-specific traits. Here, we discuss these findings. Taylor & Francis 2018-09-11 /pmc/articles/PMC6154845/ /pubmed/30263947 http://dx.doi.org/10.1080/23723556.2018.1506684 Text en © 2018 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Muta, Yu
Matsuda, Michiyuki
Imajo, Masamichi
Dynamic ERK signaling regulation in intestinal tumorigenesis
title Dynamic ERK signaling regulation in intestinal tumorigenesis
title_full Dynamic ERK signaling regulation in intestinal tumorigenesis
title_fullStr Dynamic ERK signaling regulation in intestinal tumorigenesis
title_full_unstemmed Dynamic ERK signaling regulation in intestinal tumorigenesis
title_short Dynamic ERK signaling regulation in intestinal tumorigenesis
title_sort dynamic erk signaling regulation in intestinal tumorigenesis
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154845/
https://www.ncbi.nlm.nih.gov/pubmed/30263947
http://dx.doi.org/10.1080/23723556.2018.1506684
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AT matsudamichiyuki dynamicerksignalingregulationinintestinaltumorigenesis
AT imajomasamichi dynamicerksignalingregulationinintestinaltumorigenesis

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