Cdk6: At the interface of Rb and p53

In cancer the activity of cyclin-dependent kinase 4-(CDK4) and cyclin-dependent kinase 6 (CDK6)-cyclin complexes are frequently altered with enhanced CDK6 expression found in hematopoietic malignancies. Our latest findings show a so far unknown role of Cdk6 during oncogene-induced stress and transfo...

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Autores principales: Nebenfuehr, Sofie, Bellutti, Florian, Sexl, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154857/
https://www.ncbi.nlm.nih.gov/pubmed/30263948
http://dx.doi.org/10.1080/23723556.2018.1511206
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author Nebenfuehr, Sofie
Bellutti, Florian
Sexl, Veronika
author_facet Nebenfuehr, Sofie
Bellutti, Florian
Sexl, Veronika
author_sort Nebenfuehr, Sofie
collection PubMed
description In cancer the activity of cyclin-dependent kinase 4-(CDK4) and cyclin-dependent kinase 6 (CDK6)-cyclin complexes are frequently altered with enhanced CDK6 expression found in hematopoietic malignancies. Our latest findings show a so far unknown role of Cdk6 during oncogene-induced stress and transformation. Therein Cdk6 antagonizes p53 responses and subsequently shapes the critical decision between survival and apoptosis in pre-leukemic cells.
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spelling pubmed-61548572019-09-05 Cdk6: At the interface of Rb and p53 Nebenfuehr, Sofie Bellutti, Florian Sexl, Veronika Mol Cell Oncol Author’s Views In cancer the activity of cyclin-dependent kinase 4-(CDK4) and cyclin-dependent kinase 6 (CDK6)-cyclin complexes are frequently altered with enhanced CDK6 expression found in hematopoietic malignancies. Our latest findings show a so far unknown role of Cdk6 during oncogene-induced stress and transformation. Therein Cdk6 antagonizes p53 responses and subsequently shapes the critical decision between survival and apoptosis in pre-leukemic cells. Taylor & Francis 2018-09-05 /pmc/articles/PMC6154857/ /pubmed/30263948 http://dx.doi.org/10.1080/23723556.2018.1511206 Text en © 2018 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Nebenfuehr, Sofie
Bellutti, Florian
Sexl, Veronika
Cdk6: At the interface of Rb and p53
title Cdk6: At the interface of Rb and p53
title_full Cdk6: At the interface of Rb and p53
title_fullStr Cdk6: At the interface of Rb and p53
title_full_unstemmed Cdk6: At the interface of Rb and p53
title_short Cdk6: At the interface of Rb and p53
title_sort cdk6: at the interface of rb and p53
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154857/
https://www.ncbi.nlm.nih.gov/pubmed/30263948
http://dx.doi.org/10.1080/23723556.2018.1511206
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