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Leptin revisited: The role of leptin in starvation
Starvation causes reductions in plasma leptin concentrations, but the physiologic impact of this observation had not been documented in the starved state. Here we discuss our recent work demonstrating that hypoleptinemia activates the hypothalamic-pituitary-adrenal (HPA) axis, increasing white adipo...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154858/ https://www.ncbi.nlm.nih.gov/pubmed/30263938 http://dx.doi.org/10.1080/23723556.2018.1435185 |
| _version_ | 1783357773502742528 |
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| author | Perry, Rachel J. |
| author_facet | Perry, Rachel J. |
| author_sort | Perry, Rachel J. |
| collection | PubMed |
| description | Starvation causes reductions in plasma leptin concentrations, but the physiologic impact of this observation had not been documented in the starved state. Here we discuss our recent work demonstrating that hypoleptinemia activates the hypothalamic-pituitary-adrenal (HPA) axis, increasing white adipose tissue (WAT) lipolysis and mediating a shift from glucose to fat metabolism to maintain euglycemia in fasted rats. |
| format | Online Article Text |
| id | pubmed-6154858 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-61548582019-05-29 Leptin revisited: The role of leptin in starvation Perry, Rachel J. Mol Cell Oncol Author's Views Starvation causes reductions in plasma leptin concentrations, but the physiologic impact of this observation had not been documented in the starved state. Here we discuss our recent work demonstrating that hypoleptinemia activates the hypothalamic-pituitary-adrenal (HPA) axis, increasing white adipose tissue (WAT) lipolysis and mediating a shift from glucose to fat metabolism to maintain euglycemia in fasted rats. Taylor & Francis 2018-05-29 /pmc/articles/PMC6154858/ /pubmed/30263938 http://dx.doi.org/10.1080/23723556.2018.1435185 Text en © 2018 The Author(s). Published by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
| spellingShingle | Author's Views Perry, Rachel J. Leptin revisited: The role of leptin in starvation |
| title | Leptin revisited: The role of leptin in starvation |
| title_full | Leptin revisited: The role of leptin in starvation |
| title_fullStr | Leptin revisited: The role of leptin in starvation |
| title_full_unstemmed | Leptin revisited: The role of leptin in starvation |
| title_short | Leptin revisited: The role of leptin in starvation |
| title_sort | leptin revisited: the role of leptin in starvation |
| topic | Author's Views |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154858/ https://www.ncbi.nlm.nih.gov/pubmed/30263938 http://dx.doi.org/10.1080/23723556.2018.1435185 |
| work_keys_str_mv | AT perryrachelj leptinrevisitedtheroleofleptininstarvation |