Histone deacetylase 11 as a key regulator of metabolism and obesity

In this thought commentary, I highlight the discoveries made by Seto and colleagues related to HDAC11 and obesity. I discuss how their reported work fills a gap in the HDAC field and comment on the clinical implications of their findings. Overall, selective inhibition of HDAC11 could be a novel pote...

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Detalles Bibliográficos
Autor principal: Bhaskara, Srividya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154867/
https://www.ncbi.nlm.nih.gov/pubmed/30126820
http://dx.doi.org/10.1016/j.ebiom.2018.08.008
Descripción
Sumario:In this thought commentary, I highlight the discoveries made by Seto and colleagues related to HDAC11 and obesity. I discuss how their reported work fills a gap in the HDAC field and comment on the clinical implications of their findings. Overall, selective inhibition of HDAC11 could be a novel potential therapeutic avenue for both obesity and diabesity, the diabetes caused by obesity. Future studies to further dissect this mechanistic link between HDAC11 and metabolic programs will pave the way for designing mechanism-based combination therapeutic strategies for these two life style diseases.

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