Faithful animal modelling of human glioma by using primary initiating cells and its implications for radiosensitization therapy

It has been reported that the ATM kinase inhibitor KU60019 preferentially radiosensitizes orthotopic high grade gliomas (HGG) driven by established U87 and U1242 cell lines bearing specific TP53 mutations. We wished to determine whether those results could be extended to tumors driven by primary gli...

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Detalles Bibliográficos
Autores principales: Frosina, Guido, Ravetti, Jean Louis, Corvò, Renzo, Fella, Mauro, Garrè, Maria Luisa, Levrero, Fabrizio, Marcello, Diana, Marubbi, Daniela, Morana, Giovanni, Mussap, Michele, Neumaier, Carlo Emanuele, Profumo, Aldo, Raso, Alessandro, Rosa, Francesca, Vagge, Stefano, Vecchio, Donatella, Verrico, Antonio, Zona, Gianluigi, Daga, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154973/
https://www.ncbi.nlm.nih.gov/pubmed/30242200
http://dx.doi.org/10.1038/s41598-018-32578-w

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