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Architecture-Guided Fluid Flow Directs Renal Biomineralization

Nephrocalcinosis often begins on a calcium phosphate deposit, at the tip of the medullo-papillary complex (MPC) known as Randall’s plaque (RP). Contextualizing proximally observed biominerals within the MPC has led us to postulate a mechanobiological switch that can trigger interstitial biomineraliz...

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Autores principales: Ho, Sunita P., Chen, Ling, Allen, Frances I., Hsi, Ryan S., Shimotake, Alex R., Wiener, Scott V., Kang, Misun, Minor, Andrew M., Stoller, Marshall L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155006/
https://www.ncbi.nlm.nih.gov/pubmed/30242165
http://dx.doi.org/10.1038/s41598-018-30717-x
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author Ho, Sunita P.
Chen, Ling
Allen, Frances I.
Hsi, Ryan S.
Shimotake, Alex R.
Wiener, Scott V.
Kang, Misun
Minor, Andrew M.
Stoller, Marshall L.
author_facet Ho, Sunita P.
Chen, Ling
Allen, Frances I.
Hsi, Ryan S.
Shimotake, Alex R.
Wiener, Scott V.
Kang, Misun
Minor, Andrew M.
Stoller, Marshall L.
author_sort Ho, Sunita P.
collection PubMed
description Nephrocalcinosis often begins on a calcium phosphate deposit, at the tip of the medullo-papillary complex (MPC) known as Randall’s plaque (RP). Contextualizing proximally observed biominerals within the MPC has led us to postulate a mechanobiological switch that can trigger interstitial biomineralization at the MPC tip, remote from the intratubular biominerals. Micro X-ray computed tomography scans of human MPCs correlated with transmission and scanning electron micrographs, and X-ray energy dispersive spectrometry demonstrated novel findings about anatomically-specific biominerals. An abundance of proximal intratubular biominerals were associated with emergence of distal interstitial RP. The fundamental architecture of the MPC and mineral densities at the proximal and distal locations of the MPC differed markedly. A predominance of plate-like minerals or radially oriented plate-like crystallites within spheroidal minerals in the proximal intratubular locations, and core-shell type crystallites within spheroidal minerals in distal interstitial locations were observed. Based on the MPC anatomic location of structure-specific biominerals, a biological switch within the mineral-free zone occurring between the proximal and distal locations is postulated. The “on” and “off” switch is dependent on changes in the pressure differential resulting from changes in tubule diameters; the “Venturi effect” changes the “circumferential strain” and culminates in interstitial crystal deposits in the distal tubule wall in response to proximal tubular obstruction. These distal interstitial mineralizations can emerge into the collecting system of the kidney linking nephrocalcinosis with nephrolithiasis.
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spelling pubmed-61550062018-09-28 Architecture-Guided Fluid Flow Directs Renal Biomineralization Ho, Sunita P. Chen, Ling Allen, Frances I. Hsi, Ryan S. Shimotake, Alex R. Wiener, Scott V. Kang, Misun Minor, Andrew M. Stoller, Marshall L. Sci Rep Article Nephrocalcinosis often begins on a calcium phosphate deposit, at the tip of the medullo-papillary complex (MPC) known as Randall’s plaque (RP). Contextualizing proximally observed biominerals within the MPC has led us to postulate a mechanobiological switch that can trigger interstitial biomineralization at the MPC tip, remote from the intratubular biominerals. Micro X-ray computed tomography scans of human MPCs correlated with transmission and scanning electron micrographs, and X-ray energy dispersive spectrometry demonstrated novel findings about anatomically-specific biominerals. An abundance of proximal intratubular biominerals were associated with emergence of distal interstitial RP. The fundamental architecture of the MPC and mineral densities at the proximal and distal locations of the MPC differed markedly. A predominance of plate-like minerals or radially oriented plate-like crystallites within spheroidal minerals in the proximal intratubular locations, and core-shell type crystallites within spheroidal minerals in distal interstitial locations were observed. Based on the MPC anatomic location of structure-specific biominerals, a biological switch within the mineral-free zone occurring between the proximal and distal locations is postulated. The “on” and “off” switch is dependent on changes in the pressure differential resulting from changes in tubule diameters; the “Venturi effect” changes the “circumferential strain” and culminates in interstitial crystal deposits in the distal tubule wall in response to proximal tubular obstruction. These distal interstitial mineralizations can emerge into the collecting system of the kidney linking nephrocalcinosis with nephrolithiasis. Nature Publishing Group UK 2018-09-21 /pmc/articles/PMC6155006/ /pubmed/30242165 http://dx.doi.org/10.1038/s41598-018-30717-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ho, Sunita P.
Chen, Ling
Allen, Frances I.
Hsi, Ryan S.
Shimotake, Alex R.
Wiener, Scott V.
Kang, Misun
Minor, Andrew M.
Stoller, Marshall L.
Architecture-Guided Fluid Flow Directs Renal Biomineralization
title Architecture-Guided Fluid Flow Directs Renal Biomineralization
title_full Architecture-Guided Fluid Flow Directs Renal Biomineralization
title_fullStr Architecture-Guided Fluid Flow Directs Renal Biomineralization
title_full_unstemmed Architecture-Guided Fluid Flow Directs Renal Biomineralization
title_short Architecture-Guided Fluid Flow Directs Renal Biomineralization
title_sort architecture-guided fluid flow directs renal biomineralization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155006/
https://www.ncbi.nlm.nih.gov/pubmed/30242165
http://dx.doi.org/10.1038/s41598-018-30717-x
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