The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat

It is widely accepted that the periodic cycle of hair follicles is controlled by the biological clock, but the molecular regulatory mechanisms of the hair follicle cycle have not been thoroughly studied. The secondary hair follicle of the cashmere goat is characterized by seasonal periodic changes t...

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Autores principales: Liu, Zhihong, Yang, Feng, Zhao, Meng, Ma, Lina, Li, Haijun, Xie, Yuchun, Nai, Rile, Che, Tianyu, Su, Rui, Zhang, Yanjun, Wang, Ruijun, Wang, Zhiying, Li, Jinquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155037/
https://www.ncbi.nlm.nih.gov/pubmed/30242252
http://dx.doi.org/10.1038/s41598-018-31986-2
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author Liu, Zhihong
Yang, Feng
Zhao, Meng
Ma, Lina
Li, Haijun
Xie, Yuchun
Nai, Rile
Che, Tianyu
Su, Rui
Zhang, Yanjun
Wang, Ruijun
Wang, Zhiying
Li, Jinquan
author_facet Liu, Zhihong
Yang, Feng
Zhao, Meng
Ma, Lina
Li, Haijun
Xie, Yuchun
Nai, Rile
Che, Tianyu
Su, Rui
Zhang, Yanjun
Wang, Ruijun
Wang, Zhiying
Li, Jinquan
author_sort Liu, Zhihong
collection PubMed
description It is widely accepted that the periodic cycle of hair follicles is controlled by the biological clock, but the molecular regulatory mechanisms of the hair follicle cycle have not been thoroughly studied. The secondary hair follicle of the cashmere goat is characterized by seasonal periodic changes throughout life. In the hair follicle cycle, the initiation of hair follicles is of great significance for hair follicle regeneration. To provide a reference for hair follicle research, our study compared differences in mRNA expression and microRNA expression during the growth and repose stages of cashmere goat skin samples. Through microRNA and mRNA association analysis, we found microRNAs and target genes that play major regulatory roles in hair follicle initiation. We further constructed an mRNA-microRNA interaction network and found that hair follicle initiation and development were related to MiR-195 and the genes CHP1, SMAD2, FZD6 and SIAH1.
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spelling pubmed-61550372018-09-28 The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat Liu, Zhihong Yang, Feng Zhao, Meng Ma, Lina Li, Haijun Xie, Yuchun Nai, Rile Che, Tianyu Su, Rui Zhang, Yanjun Wang, Ruijun Wang, Zhiying Li, Jinquan Sci Rep Article It is widely accepted that the periodic cycle of hair follicles is controlled by the biological clock, but the molecular regulatory mechanisms of the hair follicle cycle have not been thoroughly studied. The secondary hair follicle of the cashmere goat is characterized by seasonal periodic changes throughout life. In the hair follicle cycle, the initiation of hair follicles is of great significance for hair follicle regeneration. To provide a reference for hair follicle research, our study compared differences in mRNA expression and microRNA expression during the growth and repose stages of cashmere goat skin samples. Through microRNA and mRNA association analysis, we found microRNAs and target genes that play major regulatory roles in hair follicle initiation. We further constructed an mRNA-microRNA interaction network and found that hair follicle initiation and development were related to MiR-195 and the genes CHP1, SMAD2, FZD6 and SIAH1. Nature Publishing Group UK 2018-09-21 /pmc/articles/PMC6155037/ /pubmed/30242252 http://dx.doi.org/10.1038/s41598-018-31986-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Liu, Zhihong
Yang, Feng
Zhao, Meng
Ma, Lina
Li, Haijun
Xie, Yuchun
Nai, Rile
Che, Tianyu
Su, Rui
Zhang, Yanjun
Wang, Ruijun
Wang, Zhiying
Li, Jinquan
The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat
title The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat
title_full The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat
title_fullStr The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat
title_full_unstemmed The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat
title_short The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat
title_sort intragenic mrna-microrna regulatory network during telogen-anagen hair follicle transition in the cashmere goat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155037/
https://www.ncbi.nlm.nih.gov/pubmed/30242252
http://dx.doi.org/10.1038/s41598-018-31986-2
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