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Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

The Wnt signalling pathway, one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL), is activated in only a subset of patients through somatic mutations. Here we describe alternative, microenvironment-dependent mechanisms of Wnt activation in malignant B cells. We show that tumo...

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Detalles Bibliográficos
Autores principales:	Mangolini, Maurizio, Götte, Frederik, Moore, Andrew, Ammon, Tim, Oelsner, Madlen, Lutzny-Geier, Gloria, Klein-Hitpass, Ludger, Williamson, James C., Lehner, Paul J., Dürig, Jan, Möllmann, Michael, Rásó-Barnett, Lívia, Hughes, Katherine, Santoro, Antonella, Méndez-Ferrer, Simón, Oostendorp, Robert A. J., Zimber-Strobl, Ursula, Peschel, Christian, Hodson, Daniel J., Schmidt-Supprian, Marc, Ringshausen, Ingo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155045/ https://www.ncbi.nlm.nih.gov/pubmed/30242258 http://dx.doi.org/10.1038/s41467-018-06069-5

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