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Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus
Excessive sodium intake is a global risk factor for hypertension. Sodium effects on blood pressure vary from person to person; hence, high-risk group targeting based on personal genetic information can play a complementary role to ongoing population preventive approaches to reduce sodium consumption...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155053/ https://www.ncbi.nlm.nih.gov/pubmed/30242241 http://dx.doi.org/10.1038/s41598-018-32074-1 |
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author | Hachiya, Tsuyoshi Narita, Akira Ohmomo, Hideki Sutoh, Yoichi Komaki, Shohei Tanno, Kozo Satoh, Mamoru Sakata, Kiyomi Hitomi, Jiro Nakamura, Motoyuki Ogasawara, Kuniaki Yamamoto, Masayuki Sasaki, Makoto Hozawa, Atsushi Shimizu, Atsushi |
author_facet | Hachiya, Tsuyoshi Narita, Akira Ohmomo, Hideki Sutoh, Yoichi Komaki, Shohei Tanno, Kozo Satoh, Mamoru Sakata, Kiyomi Hitomi, Jiro Nakamura, Motoyuki Ogasawara, Kuniaki Yamamoto, Masayuki Sasaki, Makoto Hozawa, Atsushi Shimizu, Atsushi |
author_sort | Hachiya, Tsuyoshi |
collection | PubMed |
description | Excessive sodium intake is a global risk factor for hypertension. Sodium effects on blood pressure vary from person to person; hence, high-risk group targeting based on personal genetic information can play a complementary role to ongoing population preventive approaches to reduce sodium consumption. To identify genetic factors that modulate sodium effects on blood pressure, we conducted a population-based genome-wide interaction analysis in 8,768 Japanese subjects, which was >3 times larger than a similar previous study. We tested 7,135,436 polymorphisms in the discovery cohort, and loci that met suggestive significance were further examined in an independent replication cohort. We found that an interaction between a novel 3′-BCL11B gene desert locus and daily sodium consumption was significantly associated with systolic blood pressure in both discovery and replication cohorts under the recessive model. Further statistical analysis of rs8022678, the sentinel variant of the 3′-BCL11B gene desert locus, showed that differences in mean systolic blood pressure between high and low sodium consumption subgroups were 5.9 mm Hg (P = 8.8 × 10(−12)) in rs8022678 A carriers and −0.3 mm Hg (P = 0.27) in rs8022678 A non-carriers, suggesting that the rs8022678 genotype can classify persons into sodium-sensitive (A carriers) and sodium-insensitive (A non-carriers) subgroups. Our results implied that rs8022678 A carriers may receive a greater benefit from sodium-lowering interventions than non-carriers. |
format | Online Article Text |
id | pubmed-6155053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61550532018-09-28 Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus Hachiya, Tsuyoshi Narita, Akira Ohmomo, Hideki Sutoh, Yoichi Komaki, Shohei Tanno, Kozo Satoh, Mamoru Sakata, Kiyomi Hitomi, Jiro Nakamura, Motoyuki Ogasawara, Kuniaki Yamamoto, Masayuki Sasaki, Makoto Hozawa, Atsushi Shimizu, Atsushi Sci Rep Article Excessive sodium intake is a global risk factor for hypertension. Sodium effects on blood pressure vary from person to person; hence, high-risk group targeting based on personal genetic information can play a complementary role to ongoing population preventive approaches to reduce sodium consumption. To identify genetic factors that modulate sodium effects on blood pressure, we conducted a population-based genome-wide interaction analysis in 8,768 Japanese subjects, which was >3 times larger than a similar previous study. We tested 7,135,436 polymorphisms in the discovery cohort, and loci that met suggestive significance were further examined in an independent replication cohort. We found that an interaction between a novel 3′-BCL11B gene desert locus and daily sodium consumption was significantly associated with systolic blood pressure in both discovery and replication cohorts under the recessive model. Further statistical analysis of rs8022678, the sentinel variant of the 3′-BCL11B gene desert locus, showed that differences in mean systolic blood pressure between high and low sodium consumption subgroups were 5.9 mm Hg (P = 8.8 × 10(−12)) in rs8022678 A carriers and −0.3 mm Hg (P = 0.27) in rs8022678 A non-carriers, suggesting that the rs8022678 genotype can classify persons into sodium-sensitive (A carriers) and sodium-insensitive (A non-carriers) subgroups. Our results implied that rs8022678 A carriers may receive a greater benefit from sodium-lowering interventions than non-carriers. Nature Publishing Group UK 2018-09-21 /pmc/articles/PMC6155053/ /pubmed/30242241 http://dx.doi.org/10.1038/s41598-018-32074-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hachiya, Tsuyoshi Narita, Akira Ohmomo, Hideki Sutoh, Yoichi Komaki, Shohei Tanno, Kozo Satoh, Mamoru Sakata, Kiyomi Hitomi, Jiro Nakamura, Motoyuki Ogasawara, Kuniaki Yamamoto, Masayuki Sasaki, Makoto Hozawa, Atsushi Shimizu, Atsushi Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus |
title | Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus |
title_full | Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus |
title_fullStr | Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus |
title_full_unstemmed | Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus |
title_short | Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus |
title_sort | genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-bcl11b gene desert locus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155053/ https://www.ncbi.nlm.nih.gov/pubmed/30242241 http://dx.doi.org/10.1038/s41598-018-32074-1 |
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