HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver

Adaptive responses to hypoxia regulate hepatic lipid metabolism, but their consequences in nonalcoholic fatty liver disease (NAFLD) are largely unknown. Here, we show that hypoxia inducible factor-1 (HIF-1), a key determinant of hypoxic adaptations, prevents excessive hepatic lipid accumulation in t...

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Detalles Bibliográficos
Autores principales: Arai, Takatomo, Tanaka, Masako, Goda, Nobuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155071/
https://www.ncbi.nlm.nih.gov/pubmed/30242180
http://dx.doi.org/10.1038/s41598-018-32586-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155071/
https://www.ncbi.nlm.nih.gov/pubmed/30242180
http://dx.doi.org/10.1038/s41598-018-32586-w

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