The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy

Multiple-system atrophy (MSA) is a neurodegenerative disease characterized by autonomic failure with various combinations of parkinsonism, cerebellar ataxia, and pyramidal dysfunction. We previously reported that functionally impaired variants of COQ2, which encodes an essential enzyme in the biosyn...

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Detalles Bibliográficos
Autores principales: Nakamoto, Fumiko Kusunoki, Okamoto, Satoshi, Mitsui, Jun, Sone, Takefumi, Ishikawa, Mitsuru, Yamamoto, Yorihiro, Kanegae, Yumi, Nakatake, Yuhki, Imaizumi, Kent, Ishiura, Hiroyuki, Tsuji, Shoji, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155102/
https://www.ncbi.nlm.nih.gov/pubmed/30242188
http://dx.doi.org/10.1038/s41598-018-32573-1

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