The proline–arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis

A GGGGCC repeat expansion in the C9ORF72 gene has been identified as the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. The repeat expansion undergoes unconventional translation to produce dipeptide repeat (DPR) proteins. Although it has been reported that DP...

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Detalles Bibliográficos
Autores principales: Suzuki, Hiroaki, Shibagaki, Yoshio, Hattori, Seisuke, Matsuoka, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155127/
https://www.ncbi.nlm.nih.gov/pubmed/30250194
http://dx.doi.org/10.1038/s41419-018-1028-5

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