RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation

In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate the potential roles of RIPK1 in regulating hematopoiesis and macrophage differentiation, proinflammatory activation, and cell death pathways. Knock-out of RIPK1 in hiPSCs demons...

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Detalles Bibliográficos
Autores principales: Buchrieser, Julian, Oliva-Martin, Maria Jose, Moore, Michael D., Long, Joshua C. D., Cowley, Sally A., Perez-Simón, Jose Antonio, James, William, Venero, Jose Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155173/
https://www.ncbi.nlm.nih.gov/pubmed/30250197
http://dx.doi.org/10.1038/s41419-018-1053-4

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