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Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity

Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovict...

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Autores principales: Huang, Li-Hong, Chen, Yan-Xiu, Yu, Jian-Chen, Yuan, Jie, Li, Hou-Jin, Ma, Wen-Zhe, Watanapokasin, Ramida, Hu, Kun-Chao, Niaz, Shah Iram, Yang, De-Po, Lan, Wen-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155177/
https://www.ncbi.nlm.nih.gov/pubmed/28287456
http://dx.doi.org/10.3390/molecules22030444
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author Huang, Li-Hong
Chen, Yan-Xiu
Yu, Jian-Chen
Yuan, Jie
Li, Hou-Jin
Ma, Wen-Zhe
Watanapokasin, Ramida
Hu, Kun-Chao
Niaz, Shah Iram
Yang, De-Po
Lan, Wen-Jian
author_facet Huang, Li-Hong
Chen, Yan-Xiu
Yu, Jian-Chen
Yuan, Jie
Li, Hou-Jin
Ma, Wen-Zhe
Watanapokasin, Ramida
Hu, Kun-Chao
Niaz, Shah Iram
Yang, De-Po
Lan, Wen-Jian
author_sort Huang, Li-Hong
collection PubMed
description Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovictin (4), bassiatin (5) and (3R,6R)-bassiatin (6). The structures of these compounds were determined by 1D, 2D NMR and mass spectrometry. (3R,6R)-bassiatin (6) displayed significant cytotoxic activities against the human breast cancer cell line MDA-MB-435 and the human lung cancer cell line Calu3 with IC(50) values of 7.34 ± 0.20 and 14.54 ± 0.01 μM, respectively, while bassiatin (5), the diastereomer of compound 6, was not cytotoxic.
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spelling pubmed-61551772018-11-13 Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity Huang, Li-Hong Chen, Yan-Xiu Yu, Jian-Chen Yuan, Jie Li, Hou-Jin Ma, Wen-Zhe Watanapokasin, Ramida Hu, Kun-Chao Niaz, Shah Iram Yang, De-Po Lan, Wen-Jian Molecules Article Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovictin (4), bassiatin (5) and (3R,6R)-bassiatin (6). The structures of these compounds were determined by 1D, 2D NMR and mass spectrometry. (3R,6R)-bassiatin (6) displayed significant cytotoxic activities against the human breast cancer cell line MDA-MB-435 and the human lung cancer cell line Calu3 with IC(50) values of 7.34 ± 0.20 and 14.54 ± 0.01 μM, respectively, while bassiatin (5), the diastereomer of compound 6, was not cytotoxic. MDPI 2017-03-11 /pmc/articles/PMC6155177/ /pubmed/28287456 http://dx.doi.org/10.3390/molecules22030444 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Li-Hong
Chen, Yan-Xiu
Yu, Jian-Chen
Yuan, Jie
Li, Hou-Jin
Ma, Wen-Zhe
Watanapokasin, Ramida
Hu, Kun-Chao
Niaz, Shah Iram
Yang, De-Po
Lan, Wen-Jian
Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity
title Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity
title_full Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity
title_fullStr Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity
title_full_unstemmed Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity
title_short Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity
title_sort secondary metabolites from the marine-derived fungus dichotomomyces sp. l-8 and their cytotoxic activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155177/
https://www.ncbi.nlm.nih.gov/pubmed/28287456
http://dx.doi.org/10.3390/molecules22030444
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