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Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity
Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovict...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155177/ https://www.ncbi.nlm.nih.gov/pubmed/28287456 http://dx.doi.org/10.3390/molecules22030444 |
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author | Huang, Li-Hong Chen, Yan-Xiu Yu, Jian-Chen Yuan, Jie Li, Hou-Jin Ma, Wen-Zhe Watanapokasin, Ramida Hu, Kun-Chao Niaz, Shah Iram Yang, De-Po Lan, Wen-Jian |
author_facet | Huang, Li-Hong Chen, Yan-Xiu Yu, Jian-Chen Yuan, Jie Li, Hou-Jin Ma, Wen-Zhe Watanapokasin, Ramida Hu, Kun-Chao Niaz, Shah Iram Yang, De-Po Lan, Wen-Jian |
author_sort | Huang, Li-Hong |
collection | PubMed |
description | Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovictin (4), bassiatin (5) and (3R,6R)-bassiatin (6). The structures of these compounds were determined by 1D, 2D NMR and mass spectrometry. (3R,6R)-bassiatin (6) displayed significant cytotoxic activities against the human breast cancer cell line MDA-MB-435 and the human lung cancer cell line Calu3 with IC(50) values of 7.34 ± 0.20 and 14.54 ± 0.01 μM, respectively, while bassiatin (5), the diastereomer of compound 6, was not cytotoxic. |
format | Online Article Text |
id | pubmed-6155177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61551772018-11-13 Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity Huang, Li-Hong Chen, Yan-Xiu Yu, Jian-Chen Yuan, Jie Li, Hou-Jin Ma, Wen-Zhe Watanapokasin, Ramida Hu, Kun-Chao Niaz, Shah Iram Yang, De-Po Lan, Wen-Jian Molecules Article Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovictin (4), bassiatin (5) and (3R,6R)-bassiatin (6). The structures of these compounds were determined by 1D, 2D NMR and mass spectrometry. (3R,6R)-bassiatin (6) displayed significant cytotoxic activities against the human breast cancer cell line MDA-MB-435 and the human lung cancer cell line Calu3 with IC(50) values of 7.34 ± 0.20 and 14.54 ± 0.01 μM, respectively, while bassiatin (5), the diastereomer of compound 6, was not cytotoxic. MDPI 2017-03-11 /pmc/articles/PMC6155177/ /pubmed/28287456 http://dx.doi.org/10.3390/molecules22030444 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Li-Hong Chen, Yan-Xiu Yu, Jian-Chen Yuan, Jie Li, Hou-Jin Ma, Wen-Zhe Watanapokasin, Ramida Hu, Kun-Chao Niaz, Shah Iram Yang, De-Po Lan, Wen-Jian Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity |
title | Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity |
title_full | Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity |
title_fullStr | Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity |
title_full_unstemmed | Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity |
title_short | Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity |
title_sort | secondary metabolites from the marine-derived fungus dichotomomyces sp. l-8 and their cytotoxic activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155177/ https://www.ncbi.nlm.nih.gov/pubmed/28287456 http://dx.doi.org/10.3390/molecules22030444 |
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