Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions

The reaction between benzyl amines, triethyl orthoformate, and diethyl phosphite affords either bisphosphonic (compound 1) or N-benzylaminobenzylphosphonic (compound 2) acid depending on the reaction conditions. The final output of the reaction can be manipulated by the choice of reaction conditions...

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Autores principales: Miszczyk, Patrycja, Turowska-Tyrk, Ilona, Kafarski, Paweł, Chmielewska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155184/
https://www.ncbi.nlm.nih.gov/pubmed/28287472
http://dx.doi.org/10.3390/molecules22030450
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author Miszczyk, Patrycja
Turowska-Tyrk, Ilona
Kafarski, Paweł
Chmielewska, Ewa
author_facet Miszczyk, Patrycja
Turowska-Tyrk, Ilona
Kafarski, Paweł
Chmielewska, Ewa
author_sort Miszczyk, Patrycja
collection PubMed
description The reaction between benzyl amines, triethyl orthoformate, and diethyl phosphite affords either bisphosphonic (compound 1) or N-benzylaminobenzylphosphonic (compound 2) acid depending on the reaction conditions. The final output of the reaction can be manipulated by the choice of reaction conditions, particularly the molar ratio of substrates.
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spelling pubmed-61551842018-11-13 Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions Miszczyk, Patrycja Turowska-Tyrk, Ilona Kafarski, Paweł Chmielewska, Ewa Molecules Article The reaction between benzyl amines, triethyl orthoformate, and diethyl phosphite affords either bisphosphonic (compound 1) or N-benzylaminobenzylphosphonic (compound 2) acid depending on the reaction conditions. The final output of the reaction can be manipulated by the choice of reaction conditions, particularly the molar ratio of substrates. MDPI 2017-03-11 /pmc/articles/PMC6155184/ /pubmed/28287472 http://dx.doi.org/10.3390/molecules22030450 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Miszczyk, Patrycja
Turowska-Tyrk, Ilona
Kafarski, Paweł
Chmielewska, Ewa
Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions
title Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions
title_full Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions
title_fullStr Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions
title_full_unstemmed Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions
title_short Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions
title_sort three-component reaction of benzylamines, diethyl phosphite and triethyl orthoformate: dependence of the reaction course on the structural features of the substrates and reaction conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155184/
https://www.ncbi.nlm.nih.gov/pubmed/28287472
http://dx.doi.org/10.3390/molecules22030450
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AT chmielewskaewa threecomponentreactionofbenzylaminesdiethylphosphiteandtriethylorthoformatedependenceofthereactioncourseonthestructuralfeaturesofthesubstratesandreactionconditions

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