N-Pyrrylarylsulfones with High Therapeutic Potential

This review illustrates the various studies made to investigate the activity of N-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with re...

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Detalles Bibliográficos
Autores principales: Famiglini, Valeria, Castellano, Sabrina, Silvestri, Romano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155187/
https://www.ncbi.nlm.nih.gov/pubmed/28282943
http://dx.doi.org/10.3390/molecules22030434
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author Famiglini, Valeria
Castellano, Sabrina
Silvestri, Romano
author_facet Famiglini, Valeria
Castellano, Sabrina
Silvestri, Romano
author_sort Famiglini, Valeria
collection PubMed
description This review illustrates the various studies made to investigate the activity of N-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure–activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-pyrrylarylsulfone based agents.
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spelling pubmed-61551872018-11-13 N-Pyrrylarylsulfones with High Therapeutic Potential Famiglini, Valeria Castellano, Sabrina Silvestri, Romano Molecules Review This review illustrates the various studies made to investigate the activity of N-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure–activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-pyrrylarylsulfone based agents. MDPI 2017-03-09 /pmc/articles/PMC6155187/ /pubmed/28282943 http://dx.doi.org/10.3390/molecules22030434 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Famiglini, Valeria
Castellano, Sabrina
Silvestri, Romano
N-Pyrrylarylsulfones with High Therapeutic Potential
title N-Pyrrylarylsulfones with High Therapeutic Potential
title_full N-Pyrrylarylsulfones with High Therapeutic Potential
title_fullStr N-Pyrrylarylsulfones with High Therapeutic Potential
title_full_unstemmed N-Pyrrylarylsulfones with High Therapeutic Potential
title_short N-Pyrrylarylsulfones with High Therapeutic Potential
title_sort n-pyrrylarylsulfones with high therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155187/
https://www.ncbi.nlm.nih.gov/pubmed/28282943
http://dx.doi.org/10.3390/molecules22030434
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