Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells

Sirtuin 6 (SIRT6) is a member of the NAD(+)-dependent class III deacetylase sirtuin family, which plays a key role in cancer by controlling transcription, genome stability, telomere integrity, DNA repair, and autophagy. Here we analyzed the molecular and biological effects of UBCS039, the first synt...

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Detalles Bibliográficos
Autores principales: Iachettini, Sara, Trisciuoglio, Daniela, Rotili, Dante, Lucidi, Alessia, Salvati, Erica, Zizza, Pasquale, Di Leo, Luca, Del Bufalo, Donatella, Ciriolo, Maria Rosa, Leonetti, Carlo, Steegborn, Clemens, Mai, Antonello, Rizzo, Angela, Biroccio, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155207/
https://www.ncbi.nlm.nih.gov/pubmed/30250025
http://dx.doi.org/10.1038/s41419-018-1065-0

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