PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes

Glucagon-mediated gene transcription in the liver is critical for maintaining glucose homeostasis. Promoting the induction of gluconeogenic genes and blocking that of insulin receptor substrate (Irs)2 in hepatocytes contributes to the pathogenesis of type 2 diabetes. However, the molecular mechanism...

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Detalles Bibliográficos
Autores principales: Yano, Hiroyuki, Sakai, Mashito, Matsukawa, Toshiya, Yagi, Takashi, Naganuma, Takao, Mitsushima, Masaru, Iida, Satoshi, Inaba, Yuka, Inoue, Hiroshi, Unoki-Kubota, Hiroyuki, Kaburagi, Yasushi, Asahara, Shun-ichiro, Kido, Yoshiaki, Minami, Shiro, Kasuga, Masato, Matsumoto, Michihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155226/
https://www.ncbi.nlm.nih.gov/pubmed/30250231
http://dx.doi.org/10.1038/s41598-018-32575-z

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