Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

The glycolytic PFKFB3 enzyme is widely overexpressed in cancer cells and an emerging anti-cancer target. Here, we identify PFKFB3 as a critical factor in homologous recombination (HR) repair of DNA double-strand breaks. PFKFB3 rapidly relocates into ionizing radiation (IR)-induced nuclear foci in an...

Descripción completa

Detalles Bibliográficos
Autores principales: Gustafsson, Nina M. S., Färnegårdh, Katarina, Bonagas, Nadilly, Ninou, Anna Huguet, Groth, Petra, Wiita, Elisee, Jönsson, Mattias, Hallberg, Kenth, Lehto, Jemina, Pennisi, Rosa, Martinsson, Jessica, Norström, Carina, Hollers, Jessica, Schultz, Johan, Andersson, Martin, Markova, Natalia, Marttila, Petra, Kim, Baek, Norin, Martin, Olin, Thomas, Helleday, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155239/
https://www.ncbi.nlm.nih.gov/pubmed/30250201
http://dx.doi.org/10.1038/s41467-018-06287-x

Ejemplares similares

Ejemplares similares