Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells

Cancer cells with a less differentiated stem-like phenotype are more resistant to therapeutic manipulations than their differentiated counterparts, and are considered as one of the main causes of cancer persistence and relapse. As such, induction of differentiation in cancer stem-like cells (CSLCs)...

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Detalles Bibliográficos
Autores principales: Sharif, Tanveer, Martell, Emma, Dai, Cathleen, Ghassemi-Rad, Mohammad Saleh, Lee, Kristen, Singh, Sheila K., Weaver, Ian C. G., Gujar, Shashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155240/
https://www.ncbi.nlm.nih.gov/pubmed/30250195
http://dx.doi.org/10.1038/s41419-018-0997-8

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