High PGAM5 expression induces chemoresistance by enhancing Bcl-xL-mediated anti-apoptotic signaling and predicts poor prognosis in hepatocellular carcinoma patients

Hepatocellular carcinoma (HCC) is the one of most common and deadly cancers, and is also highly resistant to conventional chemotherapy treatments. Mitochondrial phosphoglycerate mutase/protein phosphatase (PGAM5) regulates mitochondrial homeostasis and cell death, however, little is known about its...

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Detalles Bibliográficos
Autores principales: Cheng, Jingjing, Qian, Dong, Ding, Xiaofeng, Song, Tianqiang, Cai, Muyan, Dan Xie, Wang, Yuwen, Zhao, Jinlin, Liu, Zhuang, Wu, Zhiqiang, Pang, Qingsong, Zhu, Li, Wang, Ping, Hao, Xishan, Yuan, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155280/
https://www.ncbi.nlm.nih.gov/pubmed/30250224
http://dx.doi.org/10.1038/s41419-018-1017-8

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