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Pleomorphic xanthoastrocytomas of adults: MRI features, molecular markers, and clinical outcomes
Fifty adult patients with pathologically-confirmed pleomorphic xanthoastrocytomas (PXAs) were retrospectively analyzed. Adult PXAs appeared as a single lesion in 47 patients and multiple lesions in 3 patients. Temporal lobe was the most common location (17/50). Twenty-two cases were superficial with...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155288/ https://www.ncbi.nlm.nih.gov/pubmed/30250216 http://dx.doi.org/10.1038/s41598-018-32273-w |
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author | Yan, Jing Cheng, Jingliang Liu, Furong Liu, Xianzhi |
author_facet | Yan, Jing Cheng, Jingliang Liu, Furong Liu, Xianzhi |
author_sort | Yan, Jing |
collection | PubMed |
description | Fifty adult patients with pathologically-confirmed pleomorphic xanthoastrocytomas (PXAs) were retrospectively analyzed. Adult PXAs appeared as a single lesion in 47 patients and multiple lesions in 3 patients. Temporal lobe was the most common location (17/50). Twenty-two cases were superficial with obvious meningeal contact and 9 were closely adjacent to lateral ventricles. Three imaging patterns were differentiated, including a predominantly solid mass with or without cystic changes (n = 33), a predominantly cystic mass with an obvious mural nodule (n = 14), and a predominantly cystic mass with an uneven wall thickness (n = 3). The mean tumoral apparent diffusion coefficient (ADC) was 0.83 ± 0.17 × 10(−3) mm(2)/s, and the mean ADC ratio was 1.02 ± 0.22. The V-raf murine sarcoma viral oncogenes homolog B1 (BRAF)(V600E) mutation was found in 12 of 29 patients. In 36 patients with isocitrate dehydrogenases 1 and 2 (IDH1/2) data, only one had IDH1 mutation and no patient had IDH2 mutation. Anaplastic features were common (24/50) and significantly associated with high rates of recurrence or progression (P < 0.001). In conclusion, this study expands our knowledge on the MRI features, molecular markers, and clinical outcomes of adult PXAs, to some extent different from pediatric PXAs. |
format | Online Article Text |
id | pubmed-6155288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61552882018-09-28 Pleomorphic xanthoastrocytomas of adults: MRI features, molecular markers, and clinical outcomes Yan, Jing Cheng, Jingliang Liu, Furong Liu, Xianzhi Sci Rep Article Fifty adult patients with pathologically-confirmed pleomorphic xanthoastrocytomas (PXAs) were retrospectively analyzed. Adult PXAs appeared as a single lesion in 47 patients and multiple lesions in 3 patients. Temporal lobe was the most common location (17/50). Twenty-two cases were superficial with obvious meningeal contact and 9 were closely adjacent to lateral ventricles. Three imaging patterns were differentiated, including a predominantly solid mass with or without cystic changes (n = 33), a predominantly cystic mass with an obvious mural nodule (n = 14), and a predominantly cystic mass with an uneven wall thickness (n = 3). The mean tumoral apparent diffusion coefficient (ADC) was 0.83 ± 0.17 × 10(−3) mm(2)/s, and the mean ADC ratio was 1.02 ± 0.22. The V-raf murine sarcoma viral oncogenes homolog B1 (BRAF)(V600E) mutation was found in 12 of 29 patients. In 36 patients with isocitrate dehydrogenases 1 and 2 (IDH1/2) data, only one had IDH1 mutation and no patient had IDH2 mutation. Anaplastic features were common (24/50) and significantly associated with high rates of recurrence or progression (P < 0.001). In conclusion, this study expands our knowledge on the MRI features, molecular markers, and clinical outcomes of adult PXAs, to some extent different from pediatric PXAs. Nature Publishing Group UK 2018-09-24 /pmc/articles/PMC6155288/ /pubmed/30250216 http://dx.doi.org/10.1038/s41598-018-32273-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yan, Jing Cheng, Jingliang Liu, Furong Liu, Xianzhi Pleomorphic xanthoastrocytomas of adults: MRI features, molecular markers, and clinical outcomes |
title | Pleomorphic xanthoastrocytomas of adults: MRI features, molecular markers, and clinical outcomes |
title_full | Pleomorphic xanthoastrocytomas of adults: MRI features, molecular markers, and clinical outcomes |
title_fullStr | Pleomorphic xanthoastrocytomas of adults: MRI features, molecular markers, and clinical outcomes |
title_full_unstemmed | Pleomorphic xanthoastrocytomas of adults: MRI features, molecular markers, and clinical outcomes |
title_short | Pleomorphic xanthoastrocytomas of adults: MRI features, molecular markers, and clinical outcomes |
title_sort | pleomorphic xanthoastrocytomas of adults: mri features, molecular markers, and clinical outcomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155288/ https://www.ncbi.nlm.nih.gov/pubmed/30250216 http://dx.doi.org/10.1038/s41598-018-32273-w |
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