Comparison of the Sulfonamide Inhibition Profiles of the β- and γ-Carbonic Anhydrases from the Pathogenic Bacterium Burkholderia pseudomallei

We have cloned, purified, and characterized a β-carbonic anhydrase (CA, EC 4.2.1.1), BpsCAβ, from the pathogenic bacterium Burkholderia pseudomallei, responsible for the tropical disease melioidosis. The enzyme showed high catalytic activity for the physiologic CO(2) hydration reaction to bicarbonat...

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Detalles Bibliográficos
Autores principales: Vullo, Daniela, Del Prete, Sonia, Di Fonzo, Pietro, Carginale, Vincenzo, Donald, W. Alexander, Supuran, Claudiu T., Capasso, Clemente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155308/
https://www.ncbi.nlm.nih.gov/pubmed/28272358
http://dx.doi.org/10.3390/molecules22030421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155308/
https://www.ncbi.nlm.nih.gov/pubmed/28272358
http://dx.doi.org/10.3390/molecules22030421

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