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Biased signaling downstream of epidermal growth factor receptor regulates proliferative versus apoptotic response to ligand
Inhibition of epidermal growth factor receptor (EGFR) signaling by small molecule kinase inhibitors and monoclonal antibodies has proven effective in the treatment of multiple cancers. In contrast, metastatic breast cancers (BC) derived from EGFR-expressing mammary tumors are inherently resistant to...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155319/ https://www.ncbi.nlm.nih.gov/pubmed/30250119 http://dx.doi.org/10.1038/s41419-018-1034-7 |