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Biased signaling downstream of epidermal growth factor receptor regulates proliferative versus apoptotic response to ligand

Inhibition of epidermal growth factor receptor (EGFR) signaling by small molecule kinase inhibitors and monoclonal antibodies has proven effective in the treatment of multiple cancers. In contrast, metastatic breast cancers (BC) derived from EGFR-expressing mammary tumors are inherently resistant to...

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Detalles Bibliográficos
Autores principales:	Ali, Remah, Brown, Wells, Purdy, Stephen Connor, Davisson, V. Jo, Wendt, Michael K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155319/ https://www.ncbi.nlm.nih.gov/pubmed/30250119 http://dx.doi.org/10.1038/s41419-018-1034-7

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