Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

Dengue virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are transmitted by mosquitoes of the Aedes genus. During the last several decades, these viruses have been responsible for millions of cases of infection and thousands of deaths worldwide. Therefore, several investigat...

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Detalles Bibliográficos
Autores principales: Oliveira, Ana Flávia Costa da Silveira, Teixeira, Róbson Ricardo, de Oliveira, André Silva, de Souza, Ana Paula Martins, da Silva, Milene Lopes, de Paula, Sérgio Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155337/
https://www.ncbi.nlm.nih.gov/pubmed/28327521
http://dx.doi.org/10.3390/molecules22030505
Descripción
Sumario:Dengue virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are transmitted by mosquitoes of the Aedes genus. During the last several decades, these viruses have been responsible for millions of cases of infection and thousands of deaths worldwide. Therefore, several investigations were conducted over the past few years to find antiviral compounds for the treatment of DENV and CHIKV infections. One attractive strategy is the screening of compounds that target enzymes involved in the replication of both DENV and CHIKV. In this review, we describe advances in the evaluation of natural products targeting the enzymes involved in the replication of these viruses.

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