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Exploring the Antitumor Mechanism of High-Dose Cytarabine through the Metabolic Perturbations of Ribonucleotide and Deoxyribonucleotide in Human Promyelocytic Leukemia HL-60 Cells

Despite the apparent clinical benefits of high-dose cytarabine (Ara-C) over lower dose Ara-C in acute myeloid leukemia (AML) therapy, the mechanism behind high-dose Ara-C therapy remains uncertain. In this study, a LC-MS-based method was carried out to investigate the metabolic alteration of ribonuc...

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Detalles Bibliográficos
Autores principales:	Li, Zheng, Guo, Jian-Ru, Chen, Qian-Qian, Wang, Cai-Yun, Zhang, Wei-Jia, Yao, Mei-Cun, Zhang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155342/ https://www.ncbi.nlm.nih.gov/pubmed/28335578 http://dx.doi.org/10.3390/molecules22030499

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