Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents

In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the references Chloramphenicol and Trim...

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Autores principales: Gomha, Sobhi M., Farghaly, Thoraya A., Mabkhot, Yahia Nasser, Zayed, Mohie E. M., Mohamed, Amany M. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155381/
https://www.ncbi.nlm.nih.gov/pubmed/28241500
http://dx.doi.org/10.3390/molecules22030346
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author Gomha, Sobhi M.
Farghaly, Thoraya A.
Mabkhot, Yahia Nasser
Zayed, Mohie E. M.
Mohamed, Amany M. G.
author_facet Gomha, Sobhi M.
Farghaly, Thoraya A.
Mabkhot, Yahia Nasser
Zayed, Mohie E. M.
Mohamed, Amany M. G.
author_sort Gomha, Sobhi M.
collection PubMed
description In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the references Chloramphenicol and Trimethoprim/sulphamethoxazole. The antimicrobial results of the investigated compounds revealed promising results and some derivatives have activities similar to the references used.
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spelling pubmed-61553812018-11-13 Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents Gomha, Sobhi M. Farghaly, Thoraya A. Mabkhot, Yahia Nasser Zayed, Mohie E. M. Mohamed, Amany M. G. Molecules Article In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the references Chloramphenicol and Trimethoprim/sulphamethoxazole. The antimicrobial results of the investigated compounds revealed promising results and some derivatives have activities similar to the references used. MDPI 2017-02-23 /pmc/articles/PMC6155381/ /pubmed/28241500 http://dx.doi.org/10.3390/molecules22030346 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gomha, Sobhi M.
Farghaly, Thoraya A.
Mabkhot, Yahia Nasser
Zayed, Mohie E. M.
Mohamed, Amany M. G.
Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents
title Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents
title_full Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents
title_fullStr Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents
title_full_unstemmed Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents
title_short Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents
title_sort microwave-assisted synthesis of some novel azoles and azolopyrimidines as antimicrobial agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155381/
https://www.ncbi.nlm.nih.gov/pubmed/28241500
http://dx.doi.org/10.3390/molecules22030346
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