Profiling and Preparation of Metabolites from Pyragrel in Human Urine by Online Solid-Phase Extraction Coupled with High Performance Liquid Chromatography Tandem Mass Spectrometry Followed by a Macroporous Resin-Based Purification Approach

Pyragrel, a new anticoagulant drug, is derived from the molecular combination of ligustrazine and ferulic acid. Pyragrel showed significant inhibitory activity against platelet aggregation induced by adenosine diphosphate (ADP), and had been approved for a phase I clinical trial by CFDA. To characte...

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Detalles Bibliográficos
Autores principales: Zhao, Xin, Jiang, Jingjing, Yang, Guang, Huang, Jie, Yang, Guoping, He, Guangwei, Chu, Zhaoxing, Hang, Taijun, Fan, Guorong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155396/
https://www.ncbi.nlm.nih.gov/pubmed/28335566
http://dx.doi.org/10.3390/molecules22030494

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