Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum

Three new polyoxygenated briarane diterpenoids, briarenols C–E (1–3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation...

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Autores principales: Chen, Nan-Fu, Su, Yin-Di, Hwang, Tsong-Long, Liao, Zuo-Jian, Tsui, Kuan-Hao, Wen, Zhi-Hong, Wu, Yang-Chang, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155408/
https://www.ncbi.nlm.nih.gov/pubmed/28304345
http://dx.doi.org/10.3390/molecules22030475
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author Chen, Nan-Fu
Su, Yin-Di
Hwang, Tsong-Long
Liao, Zuo-Jian
Tsui, Kuan-Hao
Wen, Zhi-Hong
Wu, Yang-Chang
Sung, Ping-Jyun
author_facet Chen, Nan-Fu
Su, Yin-Di
Hwang, Tsong-Long
Liao, Zuo-Jian
Tsui, Kuan-Hao
Wen, Zhi-Hong
Wu, Yang-Chang
Sung, Ping-Jyun
author_sort Chen, Nan-Fu
collection PubMed
description Three new polyoxygenated briarane diterpenoids, briarenols C–E (1–3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC(50) value of 4.65 μM. Briarenol E (3) was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line, RAW 264.7, stimulated with lipopolysaccharides (LPS).
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spelling pubmed-61554082018-11-13 Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum Chen, Nan-Fu Su, Yin-Di Hwang, Tsong-Long Liao, Zuo-Jian Tsui, Kuan-Hao Wen, Zhi-Hong Wu, Yang-Chang Sung, Ping-Jyun Molecules Article Three new polyoxygenated briarane diterpenoids, briarenols C–E (1–3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC(50) value of 4.65 μM. Briarenol E (3) was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line, RAW 264.7, stimulated with lipopolysaccharides (LPS). MDPI 2017-03-17 /pmc/articles/PMC6155408/ /pubmed/28304345 http://dx.doi.org/10.3390/molecules22030475 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Nan-Fu
Su, Yin-Di
Hwang, Tsong-Long
Liao, Zuo-Jian
Tsui, Kuan-Hao
Wen, Zhi-Hong
Wu, Yang-Chang
Sung, Ping-Jyun
Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum
title Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum
title_full Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum
title_fullStr Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum
title_full_unstemmed Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum
title_short Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum
title_sort briarenols c–e, new polyoxygenated briaranes from the octocoral briareum excavatum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155408/
https://www.ncbi.nlm.nih.gov/pubmed/28304345
http://dx.doi.org/10.3390/molecules22030475
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