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Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance
Epilepsy is a neurological disorder affecting around 1%–2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression of ATP-binding cassette transporters is consi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155434/ https://www.ncbi.nlm.nih.gov/pubmed/28264441 http://dx.doi.org/10.3390/molecules22030365 |
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author | Grewal, Gurpreet Kaur Kukal, Samiksha Kanojia, Neha Saso, Luciano Kukreti, Shrikant Kukreti, Ritushree |
author_facet | Grewal, Gurpreet Kaur Kukal, Samiksha Kanojia, Neha Saso, Luciano Kukreti, Shrikant Kukreti, Ritushree |
author_sort | Grewal, Gurpreet Kaur |
collection | PubMed |
description | Epilepsy is a neurological disorder affecting around 1%–2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression of ATP-binding cassette transporters is considered one of the major reasons for pharmacoresistance. In this review, we have summarized the regulation of ABC transporters in response to oxidative stress due to disease and antiepileptic drugs. Further, ketogenic diet and antioxidants were examined for their role in pharmacoresistance. The understanding of signalling pathways and mechanism involved may help in identifying potential therapeutic targets and improving drug response. |
format | Online Article Text |
id | pubmed-6155434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61554342018-11-13 Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance Grewal, Gurpreet Kaur Kukal, Samiksha Kanojia, Neha Saso, Luciano Kukreti, Shrikant Kukreti, Ritushree Molecules Review Epilepsy is a neurological disorder affecting around 1%–2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression of ATP-binding cassette transporters is considered one of the major reasons for pharmacoresistance. In this review, we have summarized the regulation of ABC transporters in response to oxidative stress due to disease and antiepileptic drugs. Further, ketogenic diet and antioxidants were examined for their role in pharmacoresistance. The understanding of signalling pathways and mechanism involved may help in identifying potential therapeutic targets and improving drug response. MDPI 2017-02-27 /pmc/articles/PMC6155434/ /pubmed/28264441 http://dx.doi.org/10.3390/molecules22030365 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Grewal, Gurpreet Kaur Kukal, Samiksha Kanojia, Neha Saso, Luciano Kukreti, Shrikant Kukreti, Ritushree Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance |
title | Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance |
title_full | Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance |
title_fullStr | Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance |
title_full_unstemmed | Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance |
title_short | Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance |
title_sort | effect of oxidative stress on abc transporters: contribution to epilepsy pharmacoresistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155434/ https://www.ncbi.nlm.nih.gov/pubmed/28264441 http://dx.doi.org/10.3390/molecules22030365 |
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