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Cognitive functioning following stabilisation from first episode mania

BACKGROUND: The purpose of this study was to examine cognitive functioning in people following first-episode mania relative to a demographically similar healthy control group. METHODS: Forty-one patients, who had recently stabilised from a first manic episode, and twenty-one healthy controls, were c...

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Autores principales: Daglas, Rothanthi, Allott, Kelly, Yücel, Murat, Henry, Lisa P., Macneil, Craig A., Hasty, Melissa K., Berk, Michael, Cotton, Sue M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155457/
https://www.ncbi.nlm.nih.gov/pubmed/29250705
http://dx.doi.org/10.1186/s40345-017-0108-2
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author Daglas, Rothanthi
Allott, Kelly
Yücel, Murat
Henry, Lisa P.
Macneil, Craig A.
Hasty, Melissa K.
Berk, Michael
Cotton, Sue M.
author_facet Daglas, Rothanthi
Allott, Kelly
Yücel, Murat
Henry, Lisa P.
Macneil, Craig A.
Hasty, Melissa K.
Berk, Michael
Cotton, Sue M.
author_sort Daglas, Rothanthi
collection PubMed
description BACKGROUND: The purpose of this study was to examine cognitive functioning in people following first-episode mania relative to a demographically similar healthy control group. METHODS: Forty-one patients, who had recently stabilised from a first manic episode, and twenty-one healthy controls, were compared in an extensive cognitive assessment. RESULTS: First-episode mania participants had significantly lower Full-Scale IQ (FSIQ) relative to healthy controls; however, this finding could be driven by premorbid differences in intellectual functioning. There were no significant differences between groups in Verbal IQ (VIQ) and Performance IQ (PIQ). First-episode mania participants performed significantly poorer than healthy controls in processing speed, verbal learning and memory, working memory, and cognitive flexibility with medium-to-large effects. There were no group differences in other measures of cognition. CONCLUSIONS: Participants following first-episode mania have poorer global intelligence than healthy controls, and have cognitive difficulties in some, but not all areas of cognitive functioning. This highlights the importance of early intervention and cognitive assessment in the early course of the disorder.
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spelling pubmed-61554572018-10-09 Cognitive functioning following stabilisation from first episode mania Daglas, Rothanthi Allott, Kelly Yücel, Murat Henry, Lisa P. Macneil, Craig A. Hasty, Melissa K. Berk, Michael Cotton, Sue M. Int J Bipolar Disord Research BACKGROUND: The purpose of this study was to examine cognitive functioning in people following first-episode mania relative to a demographically similar healthy control group. METHODS: Forty-one patients, who had recently stabilised from a first manic episode, and twenty-one healthy controls, were compared in an extensive cognitive assessment. RESULTS: First-episode mania participants had significantly lower Full-Scale IQ (FSIQ) relative to healthy controls; however, this finding could be driven by premorbid differences in intellectual functioning. There were no significant differences between groups in Verbal IQ (VIQ) and Performance IQ (PIQ). First-episode mania participants performed significantly poorer than healthy controls in processing speed, verbal learning and memory, working memory, and cognitive flexibility with medium-to-large effects. There were no group differences in other measures of cognition. CONCLUSIONS: Participants following first-episode mania have poorer global intelligence than healthy controls, and have cognitive difficulties in some, but not all areas of cognitive functioning. This highlights the importance of early intervention and cognitive assessment in the early course of the disorder. Springer Berlin Heidelberg 2017-12-18 /pmc/articles/PMC6155457/ /pubmed/29250705 http://dx.doi.org/10.1186/s40345-017-0108-2 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Daglas, Rothanthi
Allott, Kelly
Yücel, Murat
Henry, Lisa P.
Macneil, Craig A.
Hasty, Melissa K.
Berk, Michael
Cotton, Sue M.
Cognitive functioning following stabilisation from first episode mania
title Cognitive functioning following stabilisation from first episode mania
title_full Cognitive functioning following stabilisation from first episode mania
title_fullStr Cognitive functioning following stabilisation from first episode mania
title_full_unstemmed Cognitive functioning following stabilisation from first episode mania
title_short Cognitive functioning following stabilisation from first episode mania
title_sort cognitive functioning following stabilisation from first episode mania
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155457/
https://www.ncbi.nlm.nih.gov/pubmed/29250705
http://dx.doi.org/10.1186/s40345-017-0108-2
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