Application of the Crystalline Sponge Method to Revise the Structure of the Phenalenone Fuliginone

The structure of fuliginone was revised from a phenyl substituted phenalenone to a hydroxyl substituted phenalenone as a result of its re-purification via HPLC with subsequent NMR analysis together with an independent synthesis and analysis of the crystal structure, which was secured via the crystal...

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Autores principales: Brkljača, Robert, Schneider, Bernd, Hidalgo, William, Otálvaro, Felipe, Ospina, Felipe, Lee, Shoukou, Hoshino, Manabu, Fujita, Makoto, Urban, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155586/
https://www.ncbi.nlm.nih.gov/pubmed/28146104
http://dx.doi.org/10.3390/molecules22020211
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author Brkljača, Robert
Schneider, Bernd
Hidalgo, William
Otálvaro, Felipe
Ospina, Felipe
Lee, Shoukou
Hoshino, Manabu
Fujita, Makoto
Urban, Sylvia
author_facet Brkljača, Robert
Schneider, Bernd
Hidalgo, William
Otálvaro, Felipe
Ospina, Felipe
Lee, Shoukou
Hoshino, Manabu
Fujita, Makoto
Urban, Sylvia
author_sort Brkljača, Robert
collection PubMed
description The structure of fuliginone was revised from a phenyl substituted phenalenone to a hydroxyl substituted phenalenone as a result of its re-purification via HPLC with subsequent NMR analysis together with an independent synthesis and analysis of the crystal structure, which was secured via the crystalline sponge method. On-flow High Performance Liquid Chromatography coupled to Nuclear Magnetic Resonance spectroscopy (HPLC-NMR) was employed to confirm the presence of the natural product in the plant extract and to monitor for any possible degradation or conversion of the compound.
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spelling pubmed-61555862018-11-13 Application of the Crystalline Sponge Method to Revise the Structure of the Phenalenone Fuliginone Brkljača, Robert Schneider, Bernd Hidalgo, William Otálvaro, Felipe Ospina, Felipe Lee, Shoukou Hoshino, Manabu Fujita, Makoto Urban, Sylvia Molecules Article The structure of fuliginone was revised from a phenyl substituted phenalenone to a hydroxyl substituted phenalenone as a result of its re-purification via HPLC with subsequent NMR analysis together with an independent synthesis and analysis of the crystal structure, which was secured via the crystalline sponge method. On-flow High Performance Liquid Chromatography coupled to Nuclear Magnetic Resonance spectroscopy (HPLC-NMR) was employed to confirm the presence of the natural product in the plant extract and to monitor for any possible degradation or conversion of the compound. MDPI 2017-01-30 /pmc/articles/PMC6155586/ /pubmed/28146104 http://dx.doi.org/10.3390/molecules22020211 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Brkljača, Robert
Schneider, Bernd
Hidalgo, William
Otálvaro, Felipe
Ospina, Felipe
Lee, Shoukou
Hoshino, Manabu
Fujita, Makoto
Urban, Sylvia
Application of the Crystalline Sponge Method to Revise the Structure of the Phenalenone Fuliginone
title Application of the Crystalline Sponge Method to Revise the Structure of the Phenalenone Fuliginone
title_full Application of the Crystalline Sponge Method to Revise the Structure of the Phenalenone Fuliginone
title_fullStr Application of the Crystalline Sponge Method to Revise the Structure of the Phenalenone Fuliginone
title_full_unstemmed Application of the Crystalline Sponge Method to Revise the Structure of the Phenalenone Fuliginone
title_short Application of the Crystalline Sponge Method to Revise the Structure of the Phenalenone Fuliginone
title_sort application of the crystalline sponge method to revise the structure of the phenalenone fuliginone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155586/
https://www.ncbi.nlm.nih.gov/pubmed/28146104
http://dx.doi.org/10.3390/molecules22020211
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