Synthesis and Single Crystal Structures of Substituted-1,3-Selenazol-2-amines †

The synthesis and X-ray single crystal structures of a series of new 4-substituted-1,3-selenazol-2-amines is reported. The efficient preparation of these compounds was carried out by two-component cyclization of the selenoureas with equimolar amounts of α-haloketones. The selenoureas were obtained f...

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Detalles Bibliográficos
Autores principales: Hua, Guoxiong, Du, Junyi, Slawin, Alexandra M. Z., Woollins, J. Derek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155636/
https://www.ncbi.nlm.nih.gov/pubmed/28036080
http://dx.doi.org/10.3390/molecules22010046
Descripción
Sumario:The synthesis and X-ray single crystal structures of a series of new 4-substituted-1,3-selenazol-2-amines is reported. The efficient preparation of these compounds was carried out by two-component cyclization of the selenoureas with equimolar amounts of α-haloketones. The selenoureas were obtained from the reaction of Woollins’ reagent with cyanamides, followed by hydrolysis with water. All new compounds have been characterized by IR spectroscopy, multi-NMR ((1)H, (13)C, (77)Se) spectroscopy, accurate mass measurement and single crystal X-ray structure analysis.

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