Cargando…

Application of the Triazolization Reaction to Afford Dihydroartemisinin Derivatives with Anti-HIV Activity

Artemisinin and synthetic derivatives of dihydroartemisinin are known to possess various biological activities. Post-functionalization of dihydroartemisinin with triazole heterocycles has been proven to lead to enhanced therapeutic potential. By using our newly developed triazolization strategy, a l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jana, Sampad, Iram, Shabina, Thomas, Joice, Hayat, Muhammad Qasim, Pannecouque, Christophe, Dehaen, Wim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155659/ https://www.ncbi.nlm.nih.gov/pubmed/28218680 http://dx.doi.org/10.3390/molecules22020303

Ejemplares similares

Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents
por: Karypidou, Konstantina, et al.
Publicado: (2018)

Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach
por: P, Rahul, et al.
Publicado: (2022)

Chloroplast Genome Sequence of Artemisia scoparia: Comparative Analyses and Screening of Mutational Hotspots
por: Iram, Shabina, et al.
Publicado: (2019)

A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions
por: Vercruysse, Thomas, et al.
Publicado: (2012)

Design, Synthesis and Anti-Lung Cancer Evaluation of 1, 2, 3-Triazole Tethered Dihydroartemisinin-Isatin Hybrids
por: Hou, Haodong, et al.
Publicado: (2021)

5-Formyltriazoles as Valuable Starting Materials for Unsymmetrically Substituted Bi-1,2,3-Triazoles
por: Vroemans, Robby, et al.
Publicado: (2020)

The Three-Component Synthesis of 4-Sulfonyl-1,2,3-triazoles via a Sequential Aerobic Copper-Catalyzed Sulfonylation and Dimroth Cyclization
por: Van Hoof, Max, et al.
Publicado: (2021)

Sequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and hydantoins
por: Vroemans, Robby, et al.
Publicado: (2018)

2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells
por: El-Gazzar, Ahmed, et al.
Publicado: (2017)

Resistance to Dihydroartemisinin
por: Cojean, Sandrine, et al.
Publicado: (2006)

Resistance to Dihydroartemisinin
por: Legrand, Eric, et al.
Publicado: (2007)

Mechanisms of Dihydroartemisinin and Dihydroartemisinin/Holotransferrin Cytotoxicity in T-Cell Lymphoma Cells
por: Wang, Qiuyan, et al.
Publicado: (2015)

Investigation of anti-HIV activity, cytotoxicity and HIV integrase inhibitory activity of polyherbal formulation BH extracts
por: Balraj, S, et al.
Publicado: (2014)

Artemisinin Analogues as Potent Inhibitors of In Vitro Hepatitis C Virus Replication
por: Obeid, Susan, et al.
Publicado: (2013)

Anticancer Activity and Molecular Mechanisms of an Ursodeoxycholic Acid Methyl Ester-Dihydroartemisinin Hybrid via a Triazole Linkage in Hepatocellular Carcinoma Cells
por: Hsu, Ya-Fen, et al.
Publicado: (2023)

Synthesis and Anti-HIV Activity of a Novel Series of Isoquinoline-Based CXCR4 Antagonists
por: Shad, Mastaneh Safarnejad, et al.
Publicado: (2021)

Pharmacologically active flavonoids from the anticancer, antioxidant and antimicrobial extracts of Cassia angustifolia Vahl
por: Ahmed, Shabina Ishtiaq, et al.
Publicado: (2016)

The pharmaceutical death-ride of dihydroartemisinin
por: Jansen, Frans Herwig
Publicado: (2010)

Assembly of fully substituted triazolochromenes via a novel multicomponent reaction or mechanochemical synthesis
por: Vroemans, Robby, et al.
Publicado: (2018)

Pilot study: bioequivalence of dihydroartemisinin in dihydroartemisinin-piperaquine tablet generic formulation in healthy Indonesian volunteers
por: Isnawati, Ani, et al.
Publicado: (2023)

Application of the Meerwein reaction of 1,4-benzoquinone to a metal-free synthesis of benzofuropyridine analogues
por: Singh, Rashmi, et al.
Publicado: (2021)

Synthesis of New Triazole-Based Thiosemicarbazone Derivatives as Anti-Alzheimer’s Disease Candidates: Evidence-Based In Vitro Study
por: Rahim, Fazal, et al.
Publicado: (2022)

Dihydroartemisinin is a Hypoxia-Active Anti-Cancer Drug in Colorectal Carcinoma Cells
por: Ontikatze, Teona, et al.
Publicado: (2014)

Design, Synthesis, and Mechanism of Dihydroartemisinin–Coumarin Hybrids as Potential Anti-Neuroinflammatory Agents
por: Yu, Haonan, et al.
Publicado: (2019)

Reduction of NADPH oxidase 4 in adipocytes contributes to the anti-obesity effect of dihydroartemisinin
por: Hua, Hu, et al.
Publicado: (2023)

HIV Screening and the Affordable Care Act
por: Carter, Greg, et al.
Publicado: (2016)

Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells
por: Huang, Tzu-En, et al.
Publicado: (2020)

Dihydroartemisinin regulates immune cell heterogeneity by triggering a cascade reaction of CDK and MAPK phosphorylation
por: Li, Qilong, et al.
Publicado: (2022)

An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives
por: Azim, Tabinda, et al.
Publicado: (2021)

Effects of dihydroartemisinin on the gut microbiome of mice
por: Liu, Yanyan, et al.
Publicado: (2020)

Dihydroartemisinin Exerts Antifibrotic and Anti-Inflammatory Effects in Graves’ Ophthalmopathy by Targeting Orbital Fibroblasts
por: Yang, Shenglan, et al.
Publicado: (2022)

Allobetulin and Its Derivatives: Synthesis and Biological Activity
por: Dehaen, Wim, et al.
Publicado: (2011)

Synthesis and post-functionalization of alternate-linked-meta-para-[2(n).1(n)]thiacyclophanes
por: De Leger, Wout, et al.
Publicado: (2018)

Design, Synthesis and Evaluation of the Antibacterial Enhancement Activities of Amino Dihydroartemisinin Derivatives
por: Wu, Chong, et al.
Publicado: (2013)

Osteogenic differentiation of adipose-derived stem cells on dihydroartemisinin electrospun nanofibers
por: Shabestani, Nazila, et al.
Publicado: (2022)

Synthesis and Antitumor Activities of Novel Mitochondria-Targeted Dihydroartemisinin Ether Derivatives
por: Xu, Cangcang, et al.
Publicado: (2022)

Development of Triazoles and Triazolium Salts Based on AZT and Their Anti-Viral Activity against HIV-1
por: de Alencar, Daniel Machado, et al.
Publicado: (2021)

Nevirapine-Based Antiretroviral Therapy Impacts Artesunate and Dihydroartemisinin Disposition in HIV-Infected Nigerian Adults
por: Fehintola, Fatai A., et al.
Publicado: (2012)

Synthesis and Evaluation of Baylis-Hillman Reaction Derived Imidazole and Triazole Cinnamates as Antifungal Agents
por: Nelson, Grady L., et al.
Publicado: (2018)

Redetermination of dihydroartemisinin at 103 (2) K
por: Jasinski, Jerry P., et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_2urbc534p3mq36bj6ibmb699rg