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The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer

Tumor metastasis is a complex process in which cells detach from the primary tumor and colonize a distant organ. Metastasis is also the main process responsible for cancer-related death. Despite the enormous efforts made to unravel the metastatic process, there is no effective therapy, and patients...

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Detalles Bibliográficos
Autores principales: Giralt, Ernest, Lo Re, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155687/
https://www.ncbi.nlm.nih.gov/pubmed/28208778
http://dx.doi.org/10.3390/molecules22020198
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author Giralt, Ernest
Lo Re, Daniele
author_facet Giralt, Ernest
Lo Re, Daniele
author_sort Giralt, Ernest
collection PubMed
description Tumor metastasis is a complex process in which cells detach from the primary tumor and colonize a distant organ. Metastasis is also the main process responsible for cancer-related death. Despite the enormous efforts made to unravel the metastatic process, there is no effective therapy, and patients with metastatic tumors have poor prognosis. In this regard, there is an urgent need for new therapeutic tools for the treatment of this disease. Small molecules with the capacity to reduce cell migration could be used to treat metastasis. Migrastatin-core analogs are naturally inspired macrocycles that inhibit pathological cell migration and are able to reduce metastasis in animal models. Migrastatin analogs can be synthesized from a common advanced intermediate. Herein we present a review of the synthetic approaches that can be used to prepare this key intermediate, together with a review of the biological activity of migrastatin-core analogs and current hypotheses concerning their mechanism of action.
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spelling pubmed-61556872018-11-13 The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer Giralt, Ernest Lo Re, Daniele Molecules Review Tumor metastasis is a complex process in which cells detach from the primary tumor and colonize a distant organ. Metastasis is also the main process responsible for cancer-related death. Despite the enormous efforts made to unravel the metastatic process, there is no effective therapy, and patients with metastatic tumors have poor prognosis. In this regard, there is an urgent need for new therapeutic tools for the treatment of this disease. Small molecules with the capacity to reduce cell migration could be used to treat metastasis. Migrastatin-core analogs are naturally inspired macrocycles that inhibit pathological cell migration and are able to reduce metastasis in animal models. Migrastatin analogs can be synthesized from a common advanced intermediate. Herein we present a review of the synthetic approaches that can be used to prepare this key intermediate, together with a review of the biological activity of migrastatin-core analogs and current hypotheses concerning their mechanism of action. MDPI 2017-02-09 /pmc/articles/PMC6155687/ /pubmed/28208778 http://dx.doi.org/10.3390/molecules22020198 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Giralt, Ernest
Lo Re, Daniele
The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer
title The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer
title_full The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer
title_fullStr The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer
title_full_unstemmed The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer
title_short The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer
title_sort therapeutic potential of migrastatin-core analogs for the treatment of metastatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155687/
https://www.ncbi.nlm.nih.gov/pubmed/28208778
http://dx.doi.org/10.3390/molecules22020198
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