Modeling of the Bioactivation of an Organic Nitrate by a Thiol to Form a Thionitrate Intermediate

Thionitrates (R–SNO(2)) have been proposed as key intermediates in the biotransformation of organic nitrates that have been used for the clinical treatment of angina pectoris for over 100 years. It has been proposed and widely accepted that a thiol would react with an organic nitrate to afford a thi...

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Detalles Bibliográficos
Autores principales: Sano, Tsukasa, Shimada, Keiichi, Aoki, Yohei, Kawashima, Takayuki, Sase, Shohei, Goto, Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155724/
https://www.ncbi.nlm.nih.gov/pubmed/28029139
http://dx.doi.org/10.3390/molecules22010019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155724/
https://www.ncbi.nlm.nih.gov/pubmed/28029139
http://dx.doi.org/10.3390/molecules22010019

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