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Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives

Indolone-N-oxides have antiplasmodial properties against Plasmodium falciparum at the erythrocytic stage, with IC(50) values in the nanomolar range. The mechanism of action of indolone derivatives involves the production of free radicals, which follows their bioreduction by an unknown mechanism. In...

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Detalles Bibliográficos
Autores principales:	Cassagnes, Laure-Estelle, Rakotoarivelo, Nambinina, Sirigu, Serena, Pério, Pierre, Najahi, Ennaji, Chavas, Léonard M. G., Thompson, Andrew, Gayon, Régis, Ferry, Gilles, Boutin, Jean A., Valentin, Alexis, Reybier, Karine, Nepveu, Françoise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155775/ https://www.ncbi.nlm.nih.gov/pubmed/28146103 http://dx.doi.org/10.3390/molecules22020210

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