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Synthesis of Novel Pyrazinamide Derivatives Based on 3-Chloropyrazine-2-carboxamide and Their Antimicrobial Evaluation

Aminodehalogenation of 3-chloropyrazine-2-carboxamide with variously substituted benzylamines yielded a series of fifteen 3-benzylaminopyrazine-2-carboxamides. Four compounds possessed in vitro whole cell activity against Mycobacterium tuberculosis H37R(v) that was at least equivalent to that of the...

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Detalles Bibliográficos
Autores principales: Jandourek, Ondrej, Tauchman, Marek, Paterova, Pavla, Konecna, Klara, Navratilova, Lucie, Kubicek, Vladimir, Holas, Ondrej, Zitko, Jan, Dolezal, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155776/
https://www.ncbi.nlm.nih.gov/pubmed/28157178
http://dx.doi.org/10.3390/molecules22020223

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