Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation

A tandem transformation of C-N coupling/C-H carbonylation has been developed for the synthesis of benzo-1,4-oxazepine pharmaceutically derivatives. Notably, this reaction was accomplished by various phenylamine with ally halides under carbon dioxide atmosphere employing 2-(2-dimethylamino-vinyl)-1H-...

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Autores principales: Zhao, Xiaojia, Zhang, Jiong, Zheng, Zeqin, Xu, Runsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155786/
https://www.ncbi.nlm.nih.gov/pubmed/28042841
http://dx.doi.org/10.3390/molecules22010053
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author Zhao, Xiaojia
Zhang, Jiong
Zheng, Zeqin
Xu, Runsheng
author_facet Zhao, Xiaojia
Zhang, Jiong
Zheng, Zeqin
Xu, Runsheng
author_sort Zhao, Xiaojia
collection PubMed
description A tandem transformation of C-N coupling/C-H carbonylation has been developed for the synthesis of benzo-1,4-oxazepine pharmaceutically derivatives. Notably, this reaction was accomplished by various phenylamine with ally halides under carbon dioxide atmosphere employing 2-(2-dimethylamino-vinyl)-1H-inden-1-olcatalyzed. Furthermore, under the optimized conditions, various benzo-1,4-oxazepine derivatives were obtained in good yields. Finally, a plausible Cu(I)/Cu(III) mechanism of C-N coupling/C-H carbonylation transformation was proposed.
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spelling pubmed-61557862018-11-13 Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation Zhao, Xiaojia Zhang, Jiong Zheng, Zeqin Xu, Runsheng Molecules Article A tandem transformation of C-N coupling/C-H carbonylation has been developed for the synthesis of benzo-1,4-oxazepine pharmaceutically derivatives. Notably, this reaction was accomplished by various phenylamine with ally halides under carbon dioxide atmosphere employing 2-(2-dimethylamino-vinyl)-1H-inden-1-olcatalyzed. Furthermore, under the optimized conditions, various benzo-1,4-oxazepine derivatives were obtained in good yields. Finally, a plausible Cu(I)/Cu(III) mechanism of C-N coupling/C-H carbonylation transformation was proposed. MDPI 2016-12-30 /pmc/articles/PMC6155786/ /pubmed/28042841 http://dx.doi.org/10.3390/molecules22010053 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhao, Xiaojia
Zhang, Jiong
Zheng, Zeqin
Xu, Runsheng
Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation
title Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation
title_full Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation
title_fullStr Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation
title_full_unstemmed Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation
title_short Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation
title_sort facile synthesis for benzo-1,4-oxazepine derivatives by tandem transformation of c-n coupling/c-h carbonylation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155786/
https://www.ncbi.nlm.nih.gov/pubmed/28042841
http://dx.doi.org/10.3390/molecules22010053
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